ArticleProceedings of the National Academy of Sciences of the United States of America2001
CmC(A/T)GG DNA methylation in mature B cell lymphoma gene silencing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 92 citations in OpenAlex.
- Article
- Mutation Rate Variation and Other Challenges in 2-LTR Dating of Primate Endogenous Retrovirus Integrations.Journal of molecular evolution · 2025Review
- Allele-Specific CG/CCWGG Methylation of the PSA Promoter Discriminates Aggressive, Indolent, and Benign Prostate Cell Lines and Is Involved in the Regulation of PSA Expression.International journal of molecular sciences · 2025Article
- Expression, DNA methylation pattern and transcription factor EPB41L3 in gastric cancer: a study of 262 cases.Cell communication and signaling : CCS · 2024Article
- Article
- Review
- Combined loss of function of two different loci of miR-15/16 drives the pathogenesis of acute myeloid leukemia.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- DNA Methylation-a Potential Source of Mitochondria DNA Base Mismatch in the Development of Diabetic Retinopathy.Molecular neurobiology · 2019Article
- Epigenetic regulation of male fate commitment from an initially bipotential system.Molecular and cellular endocrinology · 2018Review
- Methylation-Demethylation Dynamics: Implications of Changes in Acute Kidney Injury.Analytical cellular pathology (Amsterdam) · 2018Review
- Intra-Gene DNA Methylation Variability Is a Clinically Independent Prognostic Marker in Women's Cancers.PloS one · 2015Article
- The evidence for functional non-CpG methylation in mammalian cells.Epigenetics · 2014Review
- Single-base resolution of mouse offspring brain methylome reveals epigenome modifications caused by gestational folic acid.Epigenetics & chromatin · 2014Article
- Analysis of promoter non-CG methylation in prostate cancer.Epigenomics · 2013Article
- Article
- Cancer-specific methylation in the BRCA1 promoter in sporadic breast tumours.Medical oncology (Northwood, London, England) · 2011Article
- Early demethylation of non-CpG, CpC-rich, elements in the myogenin 5'-flanking region: a priming effect on the spreading of active demethylation.Cell cycle (Georgetown, Tex.) · 2010Article
- Human non-CG methylation: are human stem cells plant-like?Epigenetics · 2010Review
- Cooperative activity of DNA methyltransferases for maintenance of symmetrical and non-symmetrical cytosine methylation in Arabidopsis thaliana.The Plant journal : for cell and molecular biology · 2008Article
- Quantitative assessment of DNA methylation: Potential applications for disease diagnosis, classification, and prognosis in clinical settings.Journal of molecular medicine (Berlin, Germany) · 2006Review
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7 authors at 2 institutions in 2 countries.
Funding
Abstract
DNA methylation has been linked to gene silencing in cancer. Primary effusion lymphoma (PEL) and myeloma are lymphoid malignancies that arise from terminally differentiated B cells. Interestingly, PEL do not express immunoglobulins or most B lineage-specific genes. The B cell-specific B29 (Igbeta/CD79b) gene is silenced in PEL and some myelomas but is expressed in other normal and malignant B cells. B29 expression was reactivated in PEL by demethylating and histone deacetylase inhibiting treatments. Bisulfite sequencing revealed two types of DNA methylation in silenced B29 promoters: at conventional CpG and at CC(A/T)GG B29 promoter sites. The pattern of methylated CpG ((m)CpG) and C(m)C(A/T)GG B29 promoter methylation observed was similar to that recently reported for epigenetic silencing of an integrated retrovirus. Methylation of C(m)C(A/T)GG sites in the B29 promoter significantly repressed in vivo transcriptional activity. Also, methylation of a central conserved C(m)CTGG B29 promoter site blocked the binding of early B cell factor. This methylated motif formed DNA-protein complexes with nuclear extracts from all cell types examined. Therefore, C(m)C(A/T)GG methylation may represent an important type of epigenetic marker on mammalian DNA that impacts transcription by altering DNA-protein complex formation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.