ArticleProceedings of the National Academy of Sciences of the United States of America2001
Partitioning of a polymer into a nanoscopic protein pore obeys a simple scaling law.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Coil-Globule versus Field-Driven Coil-Blob Transitions of PEG under Nanopore Confinement.ACS measurement science au · 2026Article
- Nanopore sensing: A physical-chemical approach.Biochimica et biophysica acta. Biomembranes · 2021Review
- A comparison of ion channel current blockades caused by individual poly(ethylene glycol) molecules and polyoxometalate nanoclusters.The European physical journal. E, Soft matter · 2019Article
- Article
- Aberrantly Large Single-Channel Conductance of Polyhistidine Arm-Containing Protein Nanopores.Biochemistry · 2017Article
- Article
- Semisynthetic protein nanoreactor for single-molecule chemistry.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Theory of polymer-nanopore interactions refined using molecular dynamics simulations.Journal of the American Chemical Society · 2013Article
- Peptide translocation through the mesoscopic channel: binding kinetics at the single molecule level.European biophysics journal : EBJ · 2013Article
- Obstructing toxin pathways by targeted pore blockage.Chemical reviews · 2012Review
- Inspection of the engineered FhuA ΔC/Δ4L protein nanopore by polymer exclusion.Biophysical journal · 2012Article
- Quantitative characterization of the lipid encapsulation of quantum dots for biomedical applications.Nanomedicine : nanotechnology, biology, and medicine · 2012Article
- OccK channels from Pseudomonas aeruginosa exhibit diverse single-channel electrical signatures but conserved anion selectivity.Biochemistry · 2012Article
- Protein sensing with engineered protein nanopores.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Analysis of gating transitions among the three major open states of the OpdK channel.Biochemistry · 2011Article
- Redesign of a plugged beta-barrel membrane protein.The Journal of biological chemistry · 2011Article
- Facilitated translocation of polypeptides through a single nanopore.Journal of physics. Condensed matter : an Institute of Physics journal · 2010Article
- Single-molecule observation of protein adsorption onto an inorganic surface.Journal of the American Chemical Society · 2010Article
- Polymer partitioning and ion selectivity suggest asymmetrical shape for the membrane pore formed by epsilon toxin.Biophysical journal · 2010Article
- Applications of biological pores in nanomedicine, sensing, and nanoelectronics.Current opinion in biotechnology · 2010Review
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The dependence of the rate on polymer mass was examined for the reaction of four sulfhydryl-directed poly(ethylene glycol) reagents with cysteine residues located in the lumen of the staphylococcal alpha-hemolysin pore. The logarithms of the apparent rate constants for a particular site in the lumen were proportional to N, the number of repeat units in a polymer chain. The proportionality constant was -(a/D)(5/3), where a is the persistence length of the polymer ( approximately 3.5A) and D is the diameter of the pore. Despite some incongruencies with the assumptions of the derivation, the result suggests that the polymers partition into the lumen of the pore according to the simple scaling law of Daoud and de Gennes, c(pore)/c(solution) = exp(-N(a/D)(5/3)). Therefore, the measured reaction rates yield an estimate of the diameter of the pore and might be applied to determine the approximate dimensions of cavities within other similar proteins.
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