ArticleNucleic acids research2001
Enhancer activity of HS2 of the human beta-LCR is modulated by distance from the key nucleosome.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- A common TBP-binding site mutation elevates fetal hemoglobin levels by competitive globin switching change in β-thalassemia.Blood advances · 2025Article
- Epigenetic regulation of the circadian clock: role of 5-aza-2'-deoxycytidine.Bioscience reports · 2017Article
- Rhythmic binding of Topoisomerase I impacts on the transcription of Bmal1 and circadian period.Nucleic acids research · 2012Article
- A conserved regulatory element in the mammalian β-globin promoters.Journal of molecular evolution · 2011Article
- Dynamics of alpha-globin locus chromatin structure and gene expression during erythroid differentiation of human CD34(+) cells in culture.Experimental hematology · 2009Article
- Rhythmic SAF-A binding underlies circadian transcription of the Bmal1 gene.Molecular and cellular biology · 2008Article
- Heterogeneous nuclear ribonucleoprotein C1/C2, MeCP1, and SWI/SNF form a chromatin remodeling complex at the beta-globin locus control region.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Evolutionary conservation and functional synergism of curved DNA at the mouse epsilon- and other globin-gene promoters.Journal of molecular evolution · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A class of curved DNA appears universally in eukaryotic genomic DNA at an average distance of approximately 680 bp and shows nucleosome positioning activity by having high affinity for histone core particles in an orientation- and position-dependent manner. Here, we report that the enhancer activity at DNase I hypersensitive site 2 (HS2) of the human beta-globin locus control region (beta-LCR) can be modulated by the curved DNA located at a distance of two nucleosomes from HS2 and that the nucleosome at the curved DNA regulates nearby nucleosome phases as a key nucleosome. Erythroid-specific nucleosome phases which caused deviation of the NF-E2 (p18-p45 dimer) binding site from the nucleosome dyad axis were over-represented when the distance between the key nucleosome and HS2 exceeded 80 bp longer than the original length. At this state, enhancer activity was approximately 50% of that in the original construct, presumably due to reduced binding of transcription factors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.