ArticleNucleic acids research2001
SOX6 binds CtBP2 to repress transcription from the Fgf-3 promoter.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Different effects of three polymorphisms in MicroRNAs on cancer risk in Asian population: evidence from published literatures.PloS one · 2013Pooled it
- Protein Arginine Methyltransferases in γ-Globin Regulation and Sickle Cell Disease: Emerging Connections to Oxidative Stress.Antioxidants (Basel, Switzerland) · 2026Review
- The transcriptional repressor Ctbp2 as a metabolite sensor regulating cardiomyocytes proliferation and heart regeneration.Molecular medicine (Cambridge, Mass.) · 2025Article
- Potential association of certain microRNA gene polymorphisms with recurrent pregnancy loss susceptibility in Saudi women.PloS one · 2025Article
- Association of microRNA gene polymorphisms with recurrent spontaneous abortion: An updated meta‑analysis.Experimental and therapeutic medicine · 2023Article
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- Postnatal Sox6 Regulates Synaptic Function of Cortical Parvalbumin-Expressing Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
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- Association between miR-146a C > G, miR-149 T > C, miR-196a2 T > C, and miR-499 A > G polymorphisms and susceptibility to idiopathic recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2019Article
- CPP-E1A fusion peptides inhibit CtBP-mediated transcriptional repression.Molecular oncology · 2018Article
- Exploring digenic inheritance in arrhythmogenic cardiomyopathy.BMC medical genetics · 2017Article
- Fgf3 and Fgf16 expression patterns define spatial and temporal domains in the developing chick inner ear.Brain structure & function · 2017Article
- Article
- Recurrent miscarriage and micro-RNA among north Indian women.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Isolation of Novel CreERT2-Driver Lines in Zebrafish Using an Unbiased Gene Trap Approach.PloS one · 2015Article
- C-Terminal Binding Protein: A Molecular Link between Metabolic Imbalance and Epigenetic Regulation in Breast Cancer.International journal of cell biology · 2013Article
- Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.BMC developmental biology · 2011Article
- Sox6, jack of all trades: a versatile regulatory protein in vertebrate development.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Review
- A highly conserved SOX6 double binding site mediates SOX6 gene downregulation in erythroid cells.Nucleic acids research · 2011Article
- Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6.Genes & development · 2010Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fgf-3 is expressed in a complex pattern during mouse development. Previously, an essential regulatory element PS4A was identified in the promoter region, and shown to bind at least three factors. To identify the transcription factor(s), we used a yeast one-hybrid screen and obtained a novel Sox6 cDNA (SOX6D). When introduced into cells it strongly repressed activity from both an Fgf-3 reporter gene as well as an artificial promoter containing three PS4A elements. In situ hybridisation analysis showed that Sox6 and Fgf-3 are co-expressed in the otic vesicle of E9.5 mouse embryos in a mutually exclusive pattern, consistent with a repression of Fgf-3 transcription by SOX6. To characterise additional factor(s) involved in Fgf-3 gene repression, a yeast two-hybrid screen was used with the N-terminal portion of SOX6D. Mouse CtBP2 cDNA clones were isolated and shown to bind SOX6 in yeast and mammalian cells. Furthermore, mutational analysis of SOX6 showed that binding to CtBP2, and its responsiveness to this co-repressor, were dependent on a short amino acid sequence motif PLNLSS. Co-expression studies in NIH3T3 cells showed that SOX6 and CtBP2 co-operate to repress activity from the Fgf-3 promoter through the enhancer element PS4A. These results show that SOX6 can recruit CtBP2 to repress transcription from the Fgf-3 promoter.
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