ArticleNucleic acids research2001
Characterization of Sp1, AP-1, CBF and KRC binding sites and minisatellite DNA as functional elements of the metastasis-associated mts1/S100A4 gene intronic enhancer.
Article in Nucleic acids research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- S100A4/non-muscle myosin II signaling regulates epithelial-mesenchymal transition and stemness in uterine carcinosarcoma.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia.Leukemia · 2020Article
- ZEB1 and IL-6/11-STAT3 signalling cooperate to define invasive potential of pancreatic cancer cells via differential regulation of the expression of S100 proteins.British journal of cancer · 2019Article
- Osterix promotes the migration and angiogenesis of breast cancer by upregulation of S100A4 expression.Journal of cellular and molecular medicine · 2019Article
- Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.PLoS genetics · 2018Article
- Epigenetic silencing of miR-520c leads to induced S100A4 expression and its mediated colorectal cancer progression.Oncotarget · 2017Article
- UHRF1 is a sensor for DNA interstrand crosslinks and recruits FANCD2 to initiate the Fanconi anemia pathway.Cell reports · 2015Article
- S100 proteins as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma.Hepatitis monthly · 2012Article
- A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells.Oncogene · 2012Article
- Rho family GTPase Chp/RhoV induces PC12 apoptotic cell death via JNK activation.Small GTPases · 2011Article
- Subcellular distribution of S100A4 and its transcriptional regulation under hypoxic conditions in gastric cancer cell line BGC823.Cancer science · 2010Article
- S100A4 and metastasis: a small actor playing many roles.The American journal of pathology · 2010Review
- Predicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule mining.BMC bioinformatics · 2007Article
- A proximal activator of transcription in epithelial-mesenchymal transition.The Journal of clinical investigation · 2007Article
- Immediate and delayed effects of E-cadherin inhibition on gene regulation and cell motility in human epidermoid carcinoma cells.Molecular and cellular biology · 2005Article
- Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Article
- Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene.Oncogene · 2004Article
- Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells.The Journal of experimental medicine · 2004Article
- ZAS: C2H2 zinc finger proteins involved in growth and development.Gene expression · 2002Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The mts1/S100A4 gene encodes a small acidic calcium-binding protein that is expressed in a cell-specific manner in development, tumorigenesis and certain tissues of adult mice. A composite enhancer that is active in murine mammary adenocarcinoma cells was previously identified in the first intron of the mts1/S100A4 gene. Here we present a detailed analysis of the structure and function of this enhancer in the Mts1/S100A4-expressing CSML100 and non-expressing CSML0 mouse adenocarcinoma cell lines. In CSML100 cells the enhancer activity is composed of at least six cis-elements interacting with Sp1 and AP-1 family members and CBF/AML/PEBP2 and KRC transcription factors. In addition, a minisatellite-like DNA sequence significantly contributes to the enhancer activity via interaction with abundant proteins, which likely have been described previously under the name minisatellite-binding proteins. Extensive mutational analysis of the mts1/S100A4 enhancer revealed a cooperative function of KRC and the factors binding minisatellite DNA. This is the first example of an enhancer where two nuclear factors earlier implicated in different recombination processes cooperate to activate transcription. In Mts1/S100A4-negative CSML0 cells the strength of the enhancer was 7- to 12.5-fold lower compared to that in CSML100 cells, when referred to the activities of three viral promoters. In CSML0 cells the enhancer could be activated by exogenous AP-1 and CBF transcription factors.
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