ArticleInternational journal of hematology2001
Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice.
Article in International journal of hematology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 76 citations in OpenAlex.
- Identification of dynamic driver sets controlling phenotypical landscapes.Computational and structural biotechnology journal · 2022Article
- Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation.Nature communications · 2021Article
- Characterization and evolutionary origin of novel CHaematologica · 2021Article
- Interplay between FLI-1 and the LDB1 complex in murine erythroleukemia cells and during megakaryopoiesis.iScience · 2021Article
- Current understanding of human megakaryocytic-erythroid progenitors and their fate determinants.Current opinion in hematology · 2021Review
- Effect of YAP/TAZ on megakaryocyte differentiation and platelet production.Bioscience reports · 2020Article
- GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation.Nature communications · 2019Article
- [The role of PDK1 in the transition of endothelial to hematopoietic cells].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2018Article
- Article
- Singling out FLI1 in Paris-Trousseau syndrome.Blood · 2017Article
- Article
- Inhibition of human primary megakaryocyte differentiation by anagrelide: a gene expression profiling analysis.International journal of hematology · 2016Article
- NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes.Scientific reports · 2016Article
- Review
- Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation.Stem cell investigation · 2015Review
- MEIS1 regulates early erythroid and megakaryocytic cell fate.Haematologica · 2014Article
- FLI1 expression is correlated with breast cancer cellular growth, migration, and invasion and altered gene expression.Neoplasia (New York, N.Y.) · 2014Article
- Dynamic transcription factor activity profiles reveal key regulatory interactions during megakaryocytic and erythroid differentiation.Biotechnology and bioengineering · 2014Article
- The transcription factor Fli-1 regulates monocyte, macrophage and dendritic cell development in mice.Immunology · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Mouse embryos homozygous for a targeted disruption in the Fli-1 gene show hemorrhage into the neural tube and brain on embryonic day (E)11.0 and die shortly thereafter. Livers from the mutant embryos contain drastically reduced numbers of pronormoblasts, basophilic normoblasts, and colony-forming cells. To determine the nature of impaired hematopoiesis, we carried out cell culture studies of mutant embryonic stem (ES) cells and cells from the aorta-gonad-mesonephros (AGM) region of E10.0 mutant embryos. There was a striking reduction in the number of megakaryocytes in cultures of mutant AGM cells compared with cultures of AGM cells from wild-type or heterozygous embryos. Furthermore, Fli-1 mutant ES cells failed to produce megakaryocyte colonies and multilineage colonies containing megakaryocytes. Consistent with the observed defect in megakaryopoiesis, we also demonstrated the down-regulation of c-mpl in the AGM of mutant embryos. The percentages of pronormoblasts and basophilic normoblasts were significantly reduced in cultures of mutant AGM embryos, which contained primarily polychromatophilic and orthochromatic normoblasts. These results provide further evidence for the role of Fli-1 in the regulation of hematopoiesis and for c-mpl as a Fli-1 target gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.