Evidence map›Paper›PMID 11501882›Full record

ReviewActa odontologica Scandinavica2001

The multiple roles of major histocompatibility complex class-I-like molecules in mucosal immune function.

R S Blumberg, Y van de Wal, S Claypool, N Corazza, B Dickinson, E Nieuwenhuis, R Pitman, G Spiekermann, X Zhu, S Colgan and 1 more

Open access · diamondAbstract readReview
In one paragraph

Review in Acta odontologica Scandinavica, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Article
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

R S BlumbergGastroenterology Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. rblumberg@partners.org
Y van de Wal
S Claypool
N Corazza
B Dickinson
E Nieuwenhuis
R Pitman
G Spiekermann
X Zhu
S Colgan
W I Lencer
Harvard University · USBrigham and Women's Hospital · US

Funding

Regulation of Mucosal LymphocytesR01DK051362 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg, Yu-Hwa Huang Blumberg · 1997 to 2026
$13.5M
INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFER01DK053056 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 1997 to 2021
$10.6M
MOLECULAR CHARACTERIZATION OF MUCOSAL LYMPHOCYTESR01DK044319 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 1992 to 2026
$10.4M
Characterization of Mucosal LymphocytesR37DK044319 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 2005 to 2014
$7.2M
Intestinal Immune Regulation by IgG and FcRnR56DK053056 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 2017 to 2017
$100k
NIDDK NIH HHS DK44319NIDDK NIH HHS DK51362NIDDK NIH HHS DK53056NIDDK NIH HHS R01 DK044319NIDDK NIH HHS R01 DK051362NIDDK NIH HHS R01 DK053056NIDDK NIH HHS R37 DK044319NIDDK NIH HHS R56 DK053056
6 · The paper itself

Abstract

The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class-I genes: human leukocyte antigens (HLA) A, B, and C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa beta2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T-cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed, polymorphic proteins, the human genome also encodes several nonclassical MHC class-I-like, or class Ib, genes that, in general, encode nonpolymorphic molecules involved in various specific immunological functions. Many of these genes, including CD1, the neonatal Fc receptor for IgG, HLA-G, HLA-E, the MHC class-I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology.

Indexed as

beta 2-MicroglobulinCD8 AntigensChromosomes, Human, Pair 6Epithelial CellsGenes, MHC Class IHistocompatibility Antigens Class IHLA AntigensHumansImmunity, MucosalKiller Cells, NaturalMajor Histocompatibility ComplexMembrane GlycoproteinsReceptors, Antigen, T-CellReceptors, ImmunologicReceptors, KIRT-Lymphocytesbeta 2-MicroglobulinCD8 AntigensHistocompatibility Antigens Class IHLA AntigensMembrane GlycoproteinsReceptors, Antigen, T-CellReceptors, ImmunologicReceptors, KIR

Identifiers

PMID11501882
PMCPMC2824335
OpenAlexW2164155407

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.