ReviewJournal of mammary gland biology and neoplasia2001
Loss of chromosomal integrity in human mammary epithelial cells subsequent to escape from senescence.
Review in Journal of mammary gland biology and neoplasia, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 6 citations in OpenAlex.
- Cellular Senescence in Normal Mammary Gland and Breast Cancer. Implications for Cancer Therapy.Genes · 2022Review
- Hit-and-run epigenetic editing prevents senescence entry in primary breast cells from healthy donors.Nature communications · 2017Article
- Programmed Minichromosome Elimination as a Mechanism for Somatic Genome Reduction in Tetrahymena thermophila.PLoS genetics · 2016Article
- Genomic Changes in Normal Breast Tissue in Women at Normal Risk or at High Risk for Breast Cancer.Breast cancer : basic and clinical research · 2016Review
- Epigenome remodelling in breast cancer: insights from an early in vitro model of carcinogenesis.Breast cancer research : BCR · 2012Review
- Chromatin remodeling in mammary gland differentiation and breast tumorigenesis.Cold Spring Harbor perspectives in biology · 2010Review
- Epigenetic regulation in estrogen receptor positive breast cancer--role in treatment response.Journal of mammary gland biology and neoplasia · 2010Review
- Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies.Breast cancer research : BCR · 2010Article
- Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells.Cancer research · 2009Article
- Seed in soil, with an epigenetic view.Biochimica et biophysica acta · 2009Review
- Immortalization and transformation of human mammary epithelial cells by a tumor-derived Myc mutant.Breast cancer research and treatment · 2009Article
- Epithelial progenitors in the normal human mammary gland.Journal of mammary gland biology and neoplasia · 2005Review
- Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis.Journal of mammary gland biology and neoplasia · 2004Review
- Telomere shortening occurs early during breast tumorigenesis: a cause of chromosome destabilization underlying malignant transformation?Journal of mammary gland biology and neoplasia · 2004Review
- Loss of p53 function accelerates acquisition of telomerase activity in indefinite lifespan human mammary epithelial cell lines.Oncogene · 2003Article
- Raf-1-induced growth arrest in human mammary epithelial cells is p16-independent and is overcome in immortal cells during conversion.Oncogene · 2002Article
- Epigenetic changes accompanying human mammary epithelial cell immortalization.Journal of mammary gland biology and neoplasia · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genomic changes that foster cancer can be either genetic or epigenetic in nature. Early studies focused on genetic changes and how mutational events contribute to changes in gene expression. These point mutations, deletions and amplifications are known to activate oncogenes and inactivate tumor suppressor genes. More recently, multiple epigenetic changes that can have a profound effect on carcinogenesis have been identified. These epigenetic events, such as the methylation of promoter sequences in genes, are under active investigation. In this review we will describe a methylation event that occurs during the propagation of human mammary epithelial cells (HMEC) in culture and detail the accompanying genetic alterations that have been observed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.