ArticlePlant physiology2001
Plasma membrane phosphatidylinositol 4,5-bisphosphate levels decrease with time in culture.
Article in Plant physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- The class VIII myosin ATM2 stabilizes actin-plasma membrane contacts in tobacco pollen tubes by locally promoting PtdIns(4,5)PNature plants · 2026Article
- Phosphoinositides in plant-pathogen interaction: trends and perspectives.Stress biology · 2023Review
- Lipid kinases PIP5K7 and PIP5K9 are required for polyamine-triggered KThe Plant journal : for cell and molecular biology · 2020Article
- Phospholipid Signaling Is a Component of the Salicylic Acid Response in Plant Cell Suspension Cultures.International journal of molecular sciences · 2020Review
- Membrane Lipid Remodeling in Response to Salinity.International journal of molecular sciences · 2019Review
- Membrane Proteomic Insights into the Physiology and Taxonomy of an Oleaginous Green Microalga.Plant physiology · 2017Article
- Male functions and malfunctions: the impact of phosphoinositides on pollen development and pollen tube growth.Plant reproduction · 2016Review
- Increasing phosphatidylinositol (4,5) bisphosphate biosynthesis affects plant nuclear lipids and nuclear functions.Plant physiology and biochemistry : PPB · 2012Article
- Inositol polyphosphate 5-phosphatase7 regulates the production of reactive oxygen species and salt tolerance in Arabidopsis.Plant physiology · 2011Article
- At the poles across kingdoms: phosphoinositides and polar tip growth.Protoplasma · 2010Review
- Phospholipid signaling responses in salt-stressed rice leaves.Plant & cell physiology · 2009Article
- Phosphatidylinositol (4,5)bisphosphate inhibits K+-efflux channel activity in NT1 tobacco cultured cells.Plant physiology · 2009Article
- Tails wagging the dogs: On phosphoinositides and their fatty acyl moieties.Plant signaling & behavior · 2008Article
- Towards understanding the function of stress-inducible PtdIns(4,5)P(2) in plants.Communicative & integrative biology · 2008Article
- The type B phosphatidylinositol-4-phosphate 5-kinase 3 is essential for root hair formation in Arabidopsis thaliana.The Plant cell · 2008Article
- Increasing plasma membrane phosphatidylinositol(4,5)bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum.The Plant cell · 2007Article
- Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumulation of PtdIns(4,5)P2 and constitutive expression of the stress-response pathway.Plant physiology · 2005Article
- Osmotically induced cell swelling versus cell shrinking elicits specific changes in phospholipid signals in tobacco pollen tubes.Plant physiology · 2004Article
- Up-regulation of phosphoinositide metabolism in tobacco cells constitutively expressing the human type I inositol polyphosphate 5-phosphatase.Plant physiology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the stationary phase of growth, after 7 to 12 d in culture, the levels of phosphatidylinositol 4,5-bisphosphate (PtdInsP(2)) decreased by 75% in plasma membranes of the red alga Galdieria sulphuraria. Concomitant with the decrease in PtdInsP(2) levels in plasma membranes, there was an increase in PtdInsP(2) in microsomes, suggesting that the levels of plasma membrane PtdInsP(2) are regulated differentially. The decline of PtdInsP(2) in plasma membranes was accompanied by a 70% decrease in the specific activity of PtdInsP kinase and by reduced levels of protein cross-reacting with antisera against a conserved PtdInsP kinase domain. Upon osmotic stimulation, the loss of PtdInsP(2)from the plasma membrane increased from 10% in 7-d-old cells to 60% in 12-d-old cells, although the levels of inositol 1,4,5-trisphosphate (InsP(3)) produced in whole cells were roughly equal at both times. When cells with low plasma membrane PtdInsP(2) levels were osmotically stimulated, a mild osmotic stress (12.5 mM KCl) activated PtdInsP kinase prior to InsP(3) production, whereas in cells with high plasma membrane PtdInsP(2), more severe stress (250 mM KCl) was required to induce an increase in PtdInsP kinase activity. The differential regulation of a plasma membrane signaling pool of PtdInsP(2) is discussed with regard to the implications for understanding the responsive state of cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.