ArticleInfection and immunity2001
Cloning, expression, and catalytic activity of Helicobacter hepaticus urease.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Synthesis and evaluation of the complex-forming ability of hydroxypyranones and hydroxypyridinones with Ni (II) as possible inhibitors for urease enzyme in Helicobacter pylori.Research in pharmaceutical sciences · 2016Article
- Helicobacter hepaticus, a new pathogenic species of the Helicobacter genus: Similarities and differences with H. pylori.Iranian journal of microbiology · 2013Review
- Bioremediation: a genuine technology to remediate radionuclides from the environment.Microbial biotechnology · 2013Review
- Helicobacter hepaticus NikR controls urease and hydrogenase activities via the NikABDE and HH0418 putative nickel import proteins.Microbiology (Reading, England) · 2013Article
- Mechanisms of nickel toxicity in microorganisms.Metallomics : integrated biometal science · 2011Review
- Molecular analysis and characterization of a urease gene operon from Campylobacter sputorum biovar paraureolyticus.Folia microbiologica · 2011Article
- Functional characterization of Actinobacillus pleuropneumoniae urea transport protein, ApUT.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice.Microbial pathogenesis · 2008Article
- Nickel enzyme maturation in Helicobacter hepaticus: roles of accessory proteins in hydrogenase and urease activities.Microbiology (Reading, England) · 2007Article
- Metal-responsive gene regulation and metal transport in Helicobacter species.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2007Review
- Pathogenesis of Helicobacter pylori infection.Clinical microbiology reviews · 2006Review
- Multiplex PCR assay for differentiation of Helicobacter felis, H. bizzozeronii, and H. salomonis.Journal of clinical microbiology · 2004Article
- The complete genome sequence of the carcinogenic bacterium Helicobacter hepaticus.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- CD4+CD25+ T(R) cells suppress innate immune pathology through cytokine-dependent mechanisms.The Journal of experimental medicine · 2003Article
- Genes encoding specific nickel transport systems flank the chromosomal urease locus of pathogenic yersiniae.Journal of bacteriology · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Helicobacter hepaticus causes disease in the liver and lower intestinal tract of mice. It is strongly urease positive, although it does not live in an acidic environment. The H. hepaticus urease gene cluster was expressed in Escherichia coli with and without coexpression of the Helicobacter pylori nickel transporter NixA. As for H. pylori, it was difficult to obtain enzymatic activity from recombinant H. hepaticus urease; special conditions including NiCl2 supplementation were required. The H. hepaticus urease cluster contains a homolog of each gene in the H. pylori urease cluster, including the urea transporter gene ureI. Downstream genes were homologs of the nik nickel transport operon of E. coli. Nongastric H. hepaticus produces urease similar to that of H. pylori.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.