ArticleInfection and immunity2001
Brucella abortus HtrA functions as an authentic stress response protease but is not required for wild-type virulence in BALB/c mice.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- A SARS-CoV-2 oral vaccine development strategy based on the attenuated Salmonella type III secretion system.Journal of applied microbiology · 2022Article
- Genome-wide analysis of Brucella melitensis genes required throughout intranasal infection in mice.PLoS pathogens · 2022Article
- Article
- Proteomics of Brucella.Proteomes · 2020Review
- Genomic insights into plant growth promoting rhizobia capable of enhancing soybean germination under drought stress.BMC microbiology · 2019Article
- Chlamydia Serine Protease Inhibitor, targeting HtrA, as a New Treatment for Koala Chlamydia infection.Scientific reports · 2016Article
- RNA-seq reveals the critical role of OtpR in regulating Brucella melitensis metabolism and virulence under acidic stress.Scientific reports · 2015Article
- The HtrA-like protease CD3284 modulates virulence of Clostridium difficile.Infection and immunity · 2014Article
- Article
- Differential expression of iron acquisition genes by Brucella melitensis and Brucella canis during macrophage infection.PloS one · 2012Article
- Search for Bacillus anthracis potential vaccine candidates by a functional genomic-serologic screen.Infection and immunity · 2006Article
- Campylobacter jejuni gene expression in the chick cecum: evidence for adaptation to a low-oxygen environment.Infection and immunity · 2005Article
- The analysis of the intramacrophagic virulome of Brucella suis deciphers the environment encountered by the pathogen inside the macrophage host cell.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Shigella flexneri DegP facilitates IcsA surface expression and is required for efficient intercellular spread.Infection and immunity · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A second mutation has recently been identified in the previously described Brucella abortus htrA mutant PHE1. As a result of this finding, a new B. abortus htrA mutant, designated RWP11, was constructed to evaluate the biological function of the Brucella HtrA protease. RWP11 is more sensitive to oxidative killing in vitro and less resistant to killing by cultured murine neutrophils and macrophages than the virulent parental strain 2308 but is not attenuated in BALB/c mice through 4 weeks postinfection. The in vitro phenotype of B. abortus RWP11 is consistent with the proposed function of bacterial HtrA proteases as components of a secondary line of defense against oxidative damage. The in vivo phenotype of this mutant, however, indicates that, unlike the corresponding Salmonella and Yersinia proteins, Brucella HtrA does not play a critical role in virulence in the mouse model.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.