ArticleInfection and immunity2001
Filarial antigens impair the function of human dendritic cells during differentiation.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Filaria-induced monocyte dysfunction and its reversal following treatment.Infection and immunity · 2006Trial
- Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway.PLoS neglected tropical diseases · 2021Article
- Revisiting the Mechanisms of Immune Evasion Employed by Human Parasites.Frontiers in cellular and infection microbiology · 2021Review
- CpG enhances the immunogenicity of heterologous DNA-prime/protein-boost vaccination with the heavy chain myosin of Brugia malayi in BALB/c mice.Parasitology research · 2019Article
- Human innate lymphoid cells (ILCs) in filarial infections.Parasite immunology · 2018Review
- TLR Specific Immune Responses against Helminth Infections.Journal of parasitology research · 2017Review
- Article
- Regulatory T-cell neutralization in mice during filariasis helps in parasite clearance by enhancing T helper type 17-mediated pro-inflammatory response.Immunology · 2016Article
- Looking beyond the induction of Th2 responses to explain immunomodulation by helminths.Parasite immunology · 2015Review
- Autophagy protects monocytes from Wolbachia heat shock protein 60-induced apoptosis and senescence.PLoS neglected tropical diseases · 2015Article
- Human monocyte subsets at homeostasis and their perturbation in numbers and function in filarial infection.Infection and immunity · 2014Article
- Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses.PLoS neglected tropical diseases · 2014Article
- Article
- Recombinant Brugia malayi pepsin inhibitor (rBm33) induced monocyte function and absence of apoptotic cell death: an in vitro study.Microbial pathogenesis · 2012Article
- Regulation of global gene expression in human Loa loa infection is a function of chronicity.PLoS neglected tropical diseases · 2012Article
- Onchocerciasis: the role of Wolbachia bacterial endosymbionts in parasite biology, disease pathogenesis, and treatment.Clinical microbiology reviews · 2011Review
- Acquired immune heterogeneity and its sources in human helminth infection.Parasitology · 2011Review
- Modulation of specific and allergy-related immune responses by helminths.Journal of biomedicine & biotechnology · 2011Review
- Modulation of dendritic cell responses by parasites: a common strategy to survive.Journal of biomedicine & biotechnology · 2010Review
- CD40 and the immune response to parasitic infections.Seminars in immunology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The antigen-specific T-cell unresponsiveness seen in lymphatic filariasis is mediated, in part, by diminished antigen-presenting cell function and is most specific for microfilariae (MF), the parasite stage found in large numbers in the peripheral circulation. We investigated the effect of MF antigen (MFAg) on dendritic cells (DC) in both their differentiation process from monocyte precursors and also after they have developed into DC. When MFAg was added to cultures of monocytes during their differentiation process to immature DC, the production of interleukin 12 (IL-12) p40, p70 protein, and IL-10 was significantly (P < 0.03) inhibited in response to Staphylococcus aureus Cowan (SAC) and SAC-gamma interferon (IFN-gamma) (60% to 80% inhibition). IL-10 was also inhibited (P = 0.04) in response to CD40 ligand-IFN-gamma. Moreover, MFAg inhibited the mRNA expression of IL-12 p40 and IL-10 as assessed by RNA protection assays. This effect was antigen specific, as another parasite antigen (soluble Toxoplasma gondii antigen) did not inhibit the production of these cytokines. This effect was also not a result of diminished cell viability nor of an alteration in surface expression of most costimulatory surface molecules, including major histocompatibility complex class I and class II. In contrast to exposure throughout the differentiation process, MFAg added to immature DC had no effect on DC cytokine expression. Although MF-differentiated DC were capable of inducing an allogeneic mixed lymphocyte reaction, they did so to a significantly lesser degree than DC without antigen exposure. These data collectively suggest that once DC are differentiated from their precursor cells, they become resistant to changes by MFAg.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.