ArticleInfection and immunity2001
Induction of specific cytotoxic lymphocytes in mice vaccinated with Brucella abortus RB51.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Meta-analysis of variables affecting mouse protection efficacy of whole organism Brucella vaccines and vaccine candidates.BMC bioinformatics · 2013Pooled it
- Literature-based discovery of IFN-gamma and vaccine-mediated gene interaction networks.Journal of biomedicine & biotechnology · 2010Pooled it
- Immune biomarkers, profiles, and responses: a vaccine ontology perspective.Journal of biomedical semantics · 2026Article
- Brucellosis vaccine development: immunological mechanisms, animal models, and future directions.Archives of microbiology · 2026Review
- VaxjoGNN: A Graph Neural Network for Ontology-Grounded Vaccine Adjuvant Recommendation.bioRxiv : the preprint server for biology · 2025Article
- A novel IgG-Fc-Fused multiepitope vaccine against Brucella: robust immunogenicity.Microbial cell factories · 2025Article
- A Single Nasal Dose Vaccination with a Brucella abortus Mutant Potently Protects against Pulmonary Infection.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Brucella abortus RNA does not polarize macrophages to a particular profile but interferes with M1 polarization.PLoS neglected tropical diseases · 2022Article
- Activation of mucosal immunity as a novel therapeutic strategy for combating brucellosis.Frontiers in microbiology · 2022Review
- Targeting resident memory T cell immunity culminates in pulmonary and systemic protection against Brucella infection.PLoS pathogens · 2020Article
- Immune Response to MucosalFrontiers in immunology · 2019Review
- Immune response and differentially expressed proteins in the lung tissue of BALB/c mice challenged by aerosolized Brucella melitensis 5.The Journal of international medical research · 2018Article
- B. abortus RNA is the component involved in the down-modulation of MHC-I expression on human monocytes via TLR8 and the EGFR pathway.PLoS pathogens · 2017Article
- Inhibition of MHC-I by Brucella abortus is an early event during infection and involves EGFR pathway.Immunology and cell biology · 2017Article
- Nasal vaccination stimulates CD8(+) T cells for potent protection against mucosal Brucella melitensis challenge.Immunology and cell biology · 2016Article
- Vaxvec: The first web-based recombinant vaccine vector database and its data analysis.Vaccine · 2015Article
- Recent advances in Brucella abortus vaccines.Veterinary research · 2015Review
- Adrenal steroids modulate the immune response during Brucella abortus infection by a mechanism that depends on the regulation of cytokine production.Infection and immunity · 2015Article
- Ontology-based representation and analysis of host-Brucella interactions.Journal of biomedical semantics · 2015Article
- Immune Response of Calves Vaccinated with Brucella abortus S19 or RB51 and Revaccinated with RB51.PloS one · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A safe, more sensitive, nonradioactive, neutral red uptake assay was adopted to replace the traditional 51Cr release assay for detection of Brucella-specific cytotoxic T lymphocyte (CTL) activity. Our studies indicated that Brucella abortus strain RB51 vaccination of mice induced specific CTLs against both strain RB51- and strain 2308-infected J774.A1 macrophages but not against Listeria monocytogenes-infected J774.A1 cells. The antigen-specific cytotoxic activity was exerted by T lymphocytes but not by NK cells. CD3+ CD4+ T cells secreted the highest level of gamma interferon (IFN-gamma) and were able to exert a low but significant level of specific lysis of Brucella-infected macrophages. They also exerted a low level of nonspecific lysis of noninfected macrophages. In contrast, CD3+ CD8+ T cells secreted low levels of IFN-gamma but demonstrated high levels of specific lysis of Brucella-infected macrophages with no nonspecific lysis. These findings indicate that B. abortus strain RB51 vaccination of mice induces specific CTLs and suggest that CD3+ CD4+ and CD3+ CD8+ T cells play a synergistic role in the anti-Brucella activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.