ArticleInfection and immunity2001
Kinetics of Bartonella birtlesii infection in experimentally infected mice and pathogenic effect on reproductive functions.
Article in Infection and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- Repeated Detection ofAnimals : an open access journal from MDPI · 2025Article
- Bartonellas: could they cause reproductive disorders in humans?Revista do Instituto de Medicina Tropical de Sao Paulo · 2025Article
- Evaluation of the available animal models forOne health (Amsterdam, Netherlands) · 2024Review
- Adaptive immune defense prevents Bartonella persistence upon trans-placental transmission.PLoS pathogens · 2022Article
- Emerging rodent-associated Bartonella: a threat for human health?Parasites & vectors · 2022Review
- Article
- Prevalence of Vector-Borne Pathogens in Reproductive and Non-Reproductive Tissue Samples from Free-Roaming Domestic Cats in the South Atlantic USA.Pathogens (Basel, Switzerland) · 2021Article
- The Impact ofFrontiers in microbiology · 2021Review
- Bartonella infections in three species of Microtus: prevalence and genetic diversity, vertical transmission and the effect of concurrent Babesia microti infection on its success.Parasites & vectors · 2018Article
- Molecular Mechanisms ofFrontiers in cellular and infection microbiology · 2018Review
- Bartonella henselae AS A PUTATIVE CAUSE OF CONGENITAL CHOLESTASIS.Revista do Instituto de Medicina Tropical de Sao Paulo · 2016Article
- Bartonella infection in rodents and their flea ectoparasites: an overview.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2015Review
- Transmission dynamics of Bartonella sp. strain OE 1-1 in Sundevall's jirds (Meriones crassus).Applied and environmental microbiology · 2013Article
- Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae.Frontiers in cellular and infection microbiology · 2013Review
- Genome sequence of Bartonella birtlesii, a bacterium isolated from small rodents of the genus Apodemus.Journal of bacteriology · 2012Article
- Strategies of exploitation of mammalian reservoirs by Bartonella species.Veterinary research · 2012Review
- Intruders below the radar: molecular pathogenesis of Bartonella spp.Clinical microbiology reviews · 2012Review
- Vector competence of the tick Ixodes ricinus for transmission of Bartonella birtlesii.PLoS neglected tropical diseases · 2011Article
- Human isolates of Bartonella tamiae induce pathology in experimentally inoculated immunocompetent mice.BMC infectious diseases · 2010Article
- The Trw type IV secretion system of Bartonella mediates host-specific adhesion to erythrocytes.PLoS pathogens · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kinetics of infection and the pathogenic effects on the reproductive function of laboratory mice infected with Bartonella birtlesii recovered from an Apodemus species are described. B. birtlesii infection, as determined by bacteremia, occurred in BALB/c mice inoculated intravenously. Inoculation with a low-dose inoculum (1.5 x 10(3) CFU) induced bacteremia in only 75% of the mice compared to all of the mice inoculated with higher doses (> or =1.5 x 10(4)). Mice became bacteremic for at least 5 weeks (range, 5 to 8 weeks) with a peak ranging from 2 x 10(3) to 10(5) CFU/ml of blood. The bacteremia level was significantly higher in virgin females than in males but the duration of bacteremia was similar. In mice infected before pregnancy (n = 20), fetal loss was evaluated by enumerating resorption and fetal death on day 18 of gestation. The fetal death and resorption percentage of infected mice was 36.3% versus 14.5% for controls (P < 0.0001). Fetal suffering was evaluated by weighing viable fetuses. The weight of viable fetuses was significantly lower for infected mice than for uninfected mice (P < 0.0002). Transplacental transmission of Bartonella was demonstrated since 76% of the fetal resorptions tested was culture positive for B. birtlesii. The histopathological analysis of the placentas of infected mice showed vascular lesions in the maternal placenta, which could explain the reproductive disorders observed. BALB/c mice appeared to be a useful model for studying Bartonella infection. This study provides the first evidence of reproductive disorders in mice experimentally infected with a Bartonella strain originating from a wild rodent.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.