ArticleThe EMBO journal2001
Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- Species-specific protein-protein interactions govern the humanization of the 20S proteasome in yeast.Genetics · 2023Article
- Altered proteome in translation initiation fidelity defective eIF5Scientific reports · 2022Article
- Selective microautophagy of proteasomes is initiated by ESCRT-0 and is promoted by proteasome ubiquitylation.Journal of cell science · 2022Article
- Proteasome subunit α1 overexpression preferentially drives canonical proteasome biogenesis and enhances stress tolerance in yeast.Scientific reports · 2019Article
- Precise Post-translational Tuning Occurs for Most Protein Complex Components during Meiosis.Cell reports · 2018Article
- Principles of 60S ribosomal subunit assembly emerging from recent studies in yeast.The Biochemical journal · 2017Review
- Atomic modeling of the ITS2 ribosome assembly subcomplex from cryo-EM together with mass spectrometry-identified protein-protein crosslinks.Protein science : a publication of the Protein Society · 2017Article
- Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling.Nature structural & molecular biology · 2016Article
- Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination.G3 (Bethesda, Md.) · 2014Article
- Yeast polypeptide exit tunnel ribosomal proteins L17, L35 and L37 are necessary to recruit late-assembling factors required for 27SB pre-rRNA processing.Nucleic acids research · 2013Article
- Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3.Molecular and cellular biology · 2011Article
- Identifying eIF4E-binding protein translationally-controlled transcripts reveals links to mRNAs bound by specific PUF proteins.Nucleic acids research · 2010Article
- Towards the prediction of essential genes by integration of network topology, cellular localization and biological process information.BMC bioinformatics · 2009Article
- Recognition and processing of ubiquitin-protein conjugates by the proteasome.Annual review of biochemistry · 2009Review
- Disruption of Rpn4-induced proteasome expression in Saccharomyces cerevisiae reduces cell viability under stressed conditions.Genetics · 2008Article
- Unique role for the UbL-UbA protein Ddi1 in turnover of SCFUfo1 complexes.Molecular and cellular biology · 2006Article
- E3 ubiquitin ligase RNF2 interacts with the S6' proteasomal ATPase subunit and increases the ATP hydrolysis activity of S6'.The Biochemical journal · 2005Article
- Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases.Molecular and cellular biology · 2005Article
- Cic1p/Nsa3p is required for synthesis and nuclear export of 60S ribosomal subunits.RNA (New York, N.Y.) · 2003Article
- Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain.EMBO reports · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotes, the ubiquitin-proteasome system plays a major role in selective protein breakdown for cellular regulation. Here we report the discovery of a new essential component of this degradation machinery. We found the Saccharomyces cerevisiae protein Cic1 attached to 26S proteasomes playing a crucial role in substrate specificity for proteasomal destruction. Whereas degradation of short-lived test proteins is not affected, cic1 mutants stabilize the F-box proteins Cdc4 and Grr1, substrate recognition subunits of the SCF complex. Cic1 interacts in vitro and in vivo with Cdc4, suggesting a function as a new kind of substrate recruiting factor or adaptor associated with the proteasome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.