ArticleThe EMBO journal2001
Projection structure and molecular architecture of OxlT, a bacterial membrane transporter.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 68 citations in OpenAlex.
- Ins and Outs of Rocker Switch Mechanism in Major Facilitator Superfamily of Transporters.Membranes · 2023Review
- Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS).Chemical reviews · 2021Article
- Comparative transcriptomic analysis reveals the significant pleiotropic regulatory effects of LmbU on lincomycin biosynthesis.Microbial cell factories · 2020Article
- The Structure and Function of OxlT, the Oxalate Transporter of Oxalobacter formigenes.The Journal of membrane biology · 2015Review
- The prototypical H+/galactose symporter GalP assembles into functional trimers.Journal of molecular biology · 2010Article
- Projection structure of a member of the amino acid/polyamine/organocation transporter superfamily.The Journal of biological chemistry · 2008Article
- Modeling of glycerol-3-phosphate transporter suggests a potential 'tilt' mechanism involved in its function.Journal of bioinformatics and computational biology · 2008Article
- Ins and outs of major facilitator superfamily antiporters.Annual review of microbiology · 2008Review
- Analysis of substrate-binding elements in OxlT, the oxalate:formate antiporter of Oxalobacter formigenes.Biochemistry · 2006Article
- The 2-hydroxycarboxylate transporter family: physiology, structure, and mechanism.Microbiology and molecular biology reviews : MMBR · 2005Review
- A general channel model accounts for channel, carrier, counter-transport and co-transport kinetics.The Journal of membrane biology · 2005Article
- Functional characterization of a Na(+)-coupled dicarboxylate carrier protein from Staphylococcus aureus.Journal of bacteriology · 2005Article
- Structure and transport mechanism of the bacterial oxalate transporter OxlT.Biophysical journal · 2004Article
- Three-dimensional electron microscopic imaging of membrane invaginations in Escherichia coli overproducing the chemotaxis receptor Tsr.Journal of bacteriology · 2004Article
- Structure and function of efflux pumps that confer resistance to drugs.The Biochemical journal · 2003Review
- Electron microscopic analysis of membrane assemblies formed by the bacterial chemotaxis receptor Tsr.Journal of bacteriology · 2003Article
- Structural model for 12-helix transporters belonging to the major facilitator superfamily.Journal of bacteriology · 2003Article
- An approach to membrane protein structure without crystals.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Projection structure at 8 A resolution of the melibiose permease, an Na-sugar co-transporter from Escherichia coli.The EMBO journal · 2002Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The major facilitator superfamily (MFS) represents the largest collection of evolutionarily related members within the class of membrane 'carrier' proteins. OxlT, a representative example of the MFS, is an oxalate-transporting membrane protein in Oxalobacter formigenes. From an electron crystallographic analysis of two-dimensional crystals of OxlT, we have determined the projection structure of this membrane transporter. The projection map at 6 A resolution indicates the presence of 12 transmembrane helices in each monomer of OxlT, with one set of six helices related to the other set by an approximate internal two-fold axis. The projection map reveals the existence of a central cavity, which we propose to be part of the pathway of oxalate transport. By combining information from the projection map with related biochemical data, we present probable models for the architectural arrangement of transmembrane helices in this protein superfamily.
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