ReviewThe EMBO journal2001
New EMBO members' review: viral and bacterial proteins regulating apoptosis at the mitochondrial level.
Review in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 116 citations in OpenAlex.
- Bacterial Pyocyanin Inducible Keratin 6A Accelerates Closure of Epithelial Defect under Conditions of Mitochondrial Dysfunction.The Journal of investigative dermatology · 2023Article
- XBP1-Mediated BiP/GRP78 Upregulation Copes with Oxidative Stress in Mosquito Cells during Dengue 2 Virus Infection.BioMed research international · 2017Article
- The Acinetobacter baumannii Omp33-36 porin is a virulence factor that induces apoptosis and modulates autophagy in human cells.Infection and immunity · 2014Article
- ORF005L from infectious spleen and kidney necrosis virus is located in the inner mitochondrial membrane and induces apoptosis.Virus genes · 2014Article
- Apoptosis in HEp-2 cells infected with Ureaplasma diversum.Biological research · 2014Article
- Mitochondrial and postmitochondrial survival signaling in cancer.Mitochondrion · 2014Review
- Article
- Bioenergetics of murine lungs infected with respiratory syncytial virus.Virology journal · 2013Article
- Article
- Bioinformatic identification of Mycobacterium tuberculosis proteins likely to target host cell mitochondria: virulence factors?Microbial informatics and experimentation · 2012Article
- VDAC1: from structure to cancer therapy.Frontiers in oncology · 2012Article
- Targeting of Mycobacterium tuberculosis heparin-binding hemagglutinin to mitochondria in macrophages.PLoS pathogens · 2011Article
- Hostile takeover by Plasmodium: reorganization of parasite and host cell membranes during liver stage egress.PLoS pathogens · 2011Article
- Listeria monocytogenes transiently alters mitochondrial dynamics during infection.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mechanisms of HIV envelope-induced T lymphocyte apoptosis.Virologica Sinica · 2010Review
- Molecular determinants for subcellular localization of the severe acute respiratory syndrome coronavirus open reading frame 3b protein.Journal of virology · 2009Article
- The hepatitis E virus Orf3 protein protects cells from mitochondrial depolarization and death.The Journal of biological chemistry · 2007Article
- Mycobacterium tuberculosis nuoG is a virulence gene that inhibits apoptosis of infected host cells.PLoS pathogens · 2007Article
- Over-expression of severe acute respiratory syndrome coronavirus 3b protein induces both apoptosis and necrosis in Vero E6 cells.Virus research · 2006Article
- Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA.The Journal of cell biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondrial membrane permeabilization (MMP) is a critical step of several apoptotic pathways. Some infectious intracellular pathogens can regulate (induce or inhibit) apoptosis of their host cells at the mitochondrial level, by targeting proteins to mitochondrial membranes that either induce or inhibit MMP. Pathogen-encoded mitochondrion-targeted proteins may or may not show amino acid sequence homology to Bcl-2-like proteins. Among the Bcl-2-unrelated, mitochondrion-targeted proteins, several interact with the voltage-dependent anion channel (VDAC) or with the adenine nucleotide translocator (ANT). While VDAC-targeted proteins show homology to VDAC/porin, ANT-targeted proteins possess relatively short cationic binding domains, which may facilitate insertion into the negatively charged inner mitochondrial membrane. It may be speculated that such proteins employ pre-existing host-intrinsic mechanisms of MMP control.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.