ArticleOncogene2001
Dynamic in vivo interactions among Myc network members.
Article in Oncogene, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- MYC Binding Near Transcriptional End Sites Regulates Basal Gene Expression, Read-Through Transcription, and Intragenic Contacts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Review
- Biomedical Applications of Translational Optical Imaging: From Molecules to Humans.Molecules (Basel, Switzerland) · 2021Review
- Editorial Expression of Concern: Dynamic in vivo interactions among Myc network members.Oncogene · 2021Article
- Social stress in adolescents induces depression and brain-region-specific modulation of the transcription factor MAX.Translational psychiatry · 2016Article
- The Caenorhabditis elegans Myc-Mondo/Mad complexes integrate diverse longevity signals.PLoS genetics · 2014Article
- Modularity of the oncoprotein-like properties of platelet glycoprotein Ibalpha.The Journal of biological chemistry · 2009Article
- Evidence for a common mode of transcription factor interaction with chromatin as revealed by improved quantitative fluorescence recovery after photobleaching.Biophysical journal · 2008Article
- c-Myc downregulation: a critical molecular event in resveratrol-induced cell cycle arrest and apoptosis of human medulloblastoma cells.Journal of neuro-oncology · 2006Article
- The negative c-Myc target onzin affects proliferation and apoptosis via its obligate interaction with phospholipid scramblase 1.Molecular and cellular biology · 2006Article
- Onzin, a c-Myc-repressed target, promotes survival and transformation by modulating the Akt-Mdm2-p53 pathway.Oncogene · 2005Article
- PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts.Oncogene · 2005Article
- Use of bimolecular fluorescence complementation to demonstrate transcription factor interaction in nuclei of living cells from the filamentous fungus Acremonium chrysogenum.Current genetics · 2005Article
- Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential.Oncogene · 2004Article
- Global nature of dynamic protein-chromatin interactions in vivo: three-dimensional genome scanning and dynamic interaction networks of chromatin proteins.Molecular and cellular biology · 2004Article
- Visualization of Myc/Max/Mad family dimers and the competition for dimerization in living cells.Molecular and cellular biology · 2004Article
- Burkitt's and Burkitt-like lymphoma.Current treatment options in oncology · 2002Review
- Mxi1-0, an alternatively transcribed Mxi1 isoform, is overexpressed in glioblastomas.Neoplasia (New York, N.Y.)Article
Corrections and comments
- Expression of concern · 2021-07-29Duplication of/in Image · · see also: https://pubpeer.com/publications/86C424851DD08384F90BD4451DCADD
- Expression of concern
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Members of the Myc oncoprotein network (c-Myc, Max, and Mad) play important roles in proliferation, differentiation, and apoptosis. We expressed chimeric green fluorescent protein (GFP) fusions of c-Myc, Max, and three Mad proteins in fibroblasts. Individually, c-Myc and Mad proteins localized in subnuclear speckles, whereas Max assumed a homogeneous nuclear pattern. These distributions were co-dominant and dynamic, however, as each protein assumed the pattern of its heterodimeric partner when the latter was co-expressed at a higher level. Deletion mapping of two Mad members, Mad1 and Mxi1, demonstrated that the domains responsible for nuclear localization and speckling are separable. A non-speckling Mxi1 mutant was also less effective as a transcriptional repressor than wild-type Mxi1. c-Myc nuclear speckles were distinct from SC-35 domains involved in mRNA processing. However, in the presence of co-expressed Max, c-Myc, but not Mad, co-localized to a subset of SC-35 loci. These results show that Myc network proteins comprise dynamic subnuclear structures and behave co-dominantly when co-expressed with their normal heterodimerization partners. In addition, c-Myc-Max heterodimers, but not Max-Mad heterodimers, localize to foci actively engaged in pre-mRNA transcription/processing. These findings suggest novel means by which Myc network members promote transcriptional activation or repression.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.