ArticleAJNR. American journal of neuroradiology2001
Proton MR spectroscopic evaluation of suspicious brain lesions after stereotactic radiotherapy.
Article in AJNR. American journal of neuroradiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 170 citations in OpenAlex.
- Differentiating Radiation-Induced Necrosis from Recurrent Brain Tumor Using MR Perfusion and Spectroscopy: A Meta-Analysis.PloS one · 2016Pooled it
- Multivoxel 3D proton MR spectroscopy in the distinction of recurrent glioma from radiation injury.Journal of neuro-oncology · 2007Trial
- Clinical MR Biomarkers.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Depression and Anxiety After Radiation-Induced Brain Injury: A Review of Current Research Progress.Current oncology (Toronto, Ont.) · 2025Review
- The Utility of Spectroscopic MRI in Stereotactic Biopsy and Radiotherapy Guidance in Newly Diagnosed Glioblastoma.Tomography (Ann Arbor, Mich.) · 2024Article
- MR spectroscopy in pediatric neuroradiology.Translational pediatrics · 2021Review
- Differentiating Between Low- and High-grade Glioma Tumors Measuring Apparent Diffusion Coefficient Values in Various Regions of the Brain.Oman medical journal · 2021Article
- Advanced Imaging Techniques for Differentiating Pseudoprogression and Tumor Recurrence After Immunotherapy for Glioblastoma.Frontiers in immunology · 2021Review
- Advanced Imaging of Brain Metastases: From Augmenting Visualization and Improving Diagnosis to Evaluating Treatment Response.Frontiers in neurology · 2020Review
- Brain MR findings in patients treated with particle therapy for skull base tumors.Insights into imaging · 2019Review
- Diagnostic value of alternative techniques to gadolinium-based contrast agents in MR neuroimaging-a comprehensive overview.Insights into imaging · 2019Review
- Advanced Magnetic Resonance Imaging Techniques in Management of Brain Metastases.Frontiers in oncology · 2019Review
- [Imaging of side effects after radiation therapy].Der Radiologe · 2018Review
- Imaging in neuro-oncology.Therapeutic advances in neurological disorders · 2018Review
- Accuracy of magnetic resonance spectroscopy in distinction between radiation necrosis and recurrence of brain tumors.Iranian journal of neurology · 2015Article
- Pitfalls in the neuroimaging of glioblastoma in the era of antiangiogenic and immuno/targeted therapy - detecting illusive disease, defining response.Frontiers in neurology · 2015Review
- Pathophysiology, diagnosis, and treatment of radiation necrosis in the brain.Neurologia medico-chirurgica · 2015Review
- Recurrent glioblastoma multiforme versus radiation injury: a multiparametric 3-T MR approach.La Radiologia medica · 2014Article
- Evaluation of pseudoprogression in patients with glioblastoma multiforme using dynamic magnetic resonance imaging with ferumoxytol calls RANO criteria into question.Neuro-oncology · 2014Article
- Imaging changes following stereotactic radiosurgery for metastatic intracranial tumors: differentiating pseudoprogression from tumor progression and its effect on clinical practice.Neurosurgical review · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe radiologic assessment of suspicious brain lesions after stereotactic radiotherapy of brain tumors is difficult. The purpose of our study was to define parameters from single-voxel proton MR spectroscopy that provide a probability measure for differentiating neoplastic from radiation-induced, nonneoplastic lesions.
methodsSeventy-two lesions in 56 patients were examined using a combined MR imaging and MR spectroscopy protocol (point-resolved spectroscopy, TE = 135 ms). Signal intensities of cholines, creatines, N-acetyl aspartate, and the presence of lactate and lipid resonances were correlated to final diagnoses established by clinical and MR imaging follow-up, positron emission tomography studies, or biopsy/surgery. Statistical analysis was performed using the t test, linear discriminant analysis, and k nearest-neighbor method.
resultsSignificantly increased signal intensity ratios I(tCho)/I(tCr) (P <.0001) and I(tCho)/I(NAA) (P <.0001) were observed in neoplastic (n = 34) compared with nonneoplastic lesions (n = 32) and contralateral normal brain (n = 33). Analysis of I(tCho)/I(tCr) and I(tCho)/I(NAA) data yielded correct retrospective classification as neoplastic and nonneoplastic in 82% and 81% of the lesions, respectively. Neither I(NAA)/I(tCr) nor signal intensitities of lactate or lipids were useful for differential diagnosis.
conclusionMetabolic information provided by proton MR spectroscopy is useful for the differentiation of neoplastic and nonneoplastic brain lesions after stereotactic radiotherapy of brain tumors.
Indexed as
Identifiers
11498420PMC7975210W2136417150What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.