Evidence map›Paper›PMID 11497535›Full record

Trial reportJAMA2001

Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial.

D T Villareal, E F Binder, D B Williams, K B Schechtman, K E Yarasheski, W M Kohrt

Registry-linked trialAbstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in JAMA, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00603967 (Aromatase Inhibitors), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00603967 nacompletednot on this mapstarted 2006, after this paper: background citation

Aromatase Inhibitors: Skeletal Effects and the Role of CYP19 Gene Polymorphisms

TypeinterventionalSponsorWashington University School of MedicineRan2006 to 2009Enrolled151ConditionsBreast Cancer, PostmenopausalArmsDual x-ray absorptiometry (DXA), Blood draw, Questionnaire
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 90 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Review
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  10. Article
  11. Article
  12. Observational
  13. Calcium-41: a technology for monitoring changes in bone mineral.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Review
  14. Article
  15. Article
  16. Observational
  17. Article
  18. Review
  19. Raloxifene for older women: a review of the literature.Clinical interventions in aging · 2008
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

D T VillarealDivision of Geriatrics and Gerontology, Washington University School of Medicine, 4488 Forest Park Blvd, St Louis, MO 63108, USA. dvillare@im.wustl.edu
E F Binder
D B Williams
K B Schechtman
K E Yarasheski
W M Kohrt
Washington University in St. Louis · USUniversity of Colorado Hospital · USUniversity of Colorado Denver · US

Funding

WASHINGTON UNIVERSITY CLAUDE D PEPPER OAICP60AG013629 · NIA · WASHINGTON UNIVERSITY · PI KOHRT, WENDY M · 1995 to 2001
$1.3M
DHEA+EXERCISE-EFFECT ON SARCOPENIA &OSTEOPENIA OF AGINGK23RR016191 · NCRR · WASHINGTON UNIVERSITY · PI VILLAREAL, DENNIS T. · 2001 to 2004
$484k
NCRR NIH HHS K23 RR016191NCRR NIH HHS K23 RR16191-01NCRR NIH HHS RR00036NIA NIH HHS AG13629NIA NIH HHS P60 AG013629
6 · The paper itself

Abstract

contextAlthough hormone replacement therapy (HRT) is an established approach for osteoporosis prevention, little is known about the osteoprotective effects of HRT in frail elderly women.

objectiveTo determine whether HRT increases bone mineral density (BMD) in frail elderly women. DESIGN AND

settingRandomized, double-blind, placebo-controlled trial conducted in a US university-based research center from September 1995 to August 2000.

participantsSixty-seven women aged 75 years or older with mild-to-moderate physical frailty.

interventionParticipants were randomly assigned to receive conjugated estrogens, 0.625 mg/d, plus trimonthly medroxyprogesterone acetate, 5 mg/d for 13 days (n = 45), or matching placebo (n = 22), for 9 months.

main outcome measuresThe primary outcome measure was 9-month change in BMD of the lumbar spine and hip, measured by dual-energy x-ray absorptiometry. Secondary outcomes were changes in markers of bone turnover.

resultsBased on intention-to-treat analyses, HRT resulted in significantly larger increases in BMD of the lumbar spine than placebo (mean change, 4.3% vs 0.4%; between-group difference, 3.9%; 95% confidence interval [CI], 3.5%-4.3%) and total hip (mean change, 1.7% vs -0.1%; between-group difference, 1.8%; 95% CI, 1.5%-2.1%). Compared with placebo, HRT resulted in significant decreases in serum bone-specific alkaline phosphatase levels (mean change, -24% vs 6%; between-group difference, -30%; 95% CI, -26% to -33%) and urine N-telopeptide levels (mean change, -48% vs 4%; between-group difference, -52%; 95% CI, -47% to -55%).

conclusionsIn physically frail elderly women, 9 months of HRT significantly increased BMD compared with placebo in clinically important skeletal regions. Further studies are needed to determine whether these osteogenic effects of HRT in elderly women are associated with a reduction in osteoporotic fractures.

Indexed as

Estrogen Replacement TherapyFrail ElderlyAbsorptiometry, PhotonAgedAged, 80 and overAlkaline PhosphataseBone DensityBone RemodelingCollagenCollagen Type IDietDouble-Blind MethodEstrogens, Conjugated (USP)FemaleFemurHipAlkaline PhosphataseCollagenCollagen Type Icollagen type I trimeric cross-linked peptideEstrogens, Conjugated (USP)Medroxyprogesterone AcetatePeptides

Identifiers

PMID11497535
OpenAlexW1963970016

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.