ArticleInternational journal of impotence research2001
Effects of estrogen on nitric oxide synthase and histological composition in the rabbit clitoris and vagina.
Article in International journal of impotence research, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- Understanding sexual arousal and subjective-genital arousal desynchrony in women.Nature reviews. Urology · 2019Review
- Effect of estrogen on molecular and functional characteristics of the rodent vaginal muscularis.The journal of sexual medicine · 2013Article
- Post-translational regulation of endothelial nitric oxide synthase (eNOS) by estrogens in the rat vagina.The journal of sexual medicine · 2010Article
- Endothelial nitric oxide synthase regulation in female genital tract structures.The journal of sexual medicine · 2009Review
- General tissue characteristics of the lower urethral and vaginal walls in the domestic rabbit.International urogynecology journal and pelvic floor dysfunction · 2009Article
- Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers.BMC physiology · 2006Article
- Sex steroid hormones differentially regulate nitric oxide synthase and arginase activities in the proximal and distal rabbit vagina.International journal of impotence research · 2003Article
- Relation of sex steroid hormones to genital tissue structure and arousal: a sampling of manuscripts discussing endocrinologic sexual dysfunction.International journal of impotence research · 2003Review
- Morphological modifications in clitoris and vagina in spontaneously hypertensive rats.International journal of impotence research · 2003Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the functional and histological changes after oophorectomy in the rabbit clitoris and vagina to determine the mechanism responsible for the development of arousal disorder in postmenopausal women. Twenty mature female New Zealand white rabbits were randomly divided into three groups: control; oophorectomy; and estrogen replacement after oophorectomy. We compared the nitric oxide synthase (NOS) activity and the degree of expression of neuronal (nNOS) and endothelial NOS (eNOS) using biochemical and Western blot analysis in clitoral and vaginal tissues. Histological change of smooth muscle and collagen contents in those tissues were also compared using Masson's trichrome staining. NOS activity and the expression of nNOS and eNOS were significantly increased in the oophorectomized group while there was a decrease to the level of the control group in the estrogen replacement group. Histological examination showed that oophorectomy induced a significant increase in collagen and decrease in muscle content in both clitoris and vagina, while the ratio of smooth muscle content was increased significantly after the estrogen replacement. Our results clearly demonstrate that estrogen deficiency induces compensatory NOS production which may be related to decreases in muscle to collagen ratio in female rabbit genital organs.
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