ArticleProceedings of the National Academy of Sciences of the United States of America2001
Type I topoisomerase activity is required for proper chromosomal segregation in Escherichia coli.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 85 citations in OpenAlex.
- DNA topoisomerase I acts as supercoiling sensor for bacterial transcription elongation.Nature structural & molecular biology · 2026Article
- Topo IV is required to allow replisomes to converge and complete replication on the chromosome.PLoS genetics · 2025Article
- Whole-genome analysis of fiveMicrobiology spectrum · 2025Article
- Spatio-temporal organization of theEcoSal Plus · 2024Review
- Characterization of a pathway of genomic instability induced by R-loops and its regulation by topoisomerases in E. coli.PLoS genetics · 2023Article
- The interaction between transport-segment DNA and topoisomerase IA-crystal structure of MtbTOP1 in complex with both G- and T-segments.Nucleic acids research · 2023Article
- Topoisomerase I Essentiality, DnaA-Independent Chromosomal Replication, and Transcription-Replication Conflict in Escherichia coli.Journal of bacteriology · 2021Article
- Supercoiling, R-loops, Replication and the Functions of Bacterial Type 1A Topoisomerases.Genes · 2020Review
- Topoisomerase IV can functionally replace all type 1A topoisomerases in Bacillus subtilis.Nucleic acids research · 2019Article
- Topoisomerase III Acts at the Replication Fork To Remove Precatenanes.Journal of bacteriology · 2019Article
- Topoisomerases I and III inhibit R-loop formation to prevent unregulated replication in the chromosomal Ter region of Escherichia coli.PLoS genetics · 2018Article
- An endogenous protein inhibitor, YjhX (TopAI), for topoisomerase I from Escherichia coli.Nucleic acids research · 2015Article
- 55.2, a phage T4 ORFan gene, encodes an inhibitor of Escherichia coli topoisomerase I and increases phage fitness.PloS one · 2015Article
- Single-molecule analysis uncovers the difference between the kinetics of DNA decatenation by bacterial topoisomerases I and III.Nucleic acids research · 2014Article
- Roles of type 1A topoisomerases in genome maintenance in Escherichia coli.PLoS genetics · 2014Article
- Synthesis and dissolution of hemicatenanes by type IA DNA topoisomerases.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A novel nucleoid-associated protein specific to the actinobacteria.Nucleic acids research · 2013Article
- Interplay between type 1A topoisomerases and gyrase in chromosome segregation in Escherichia coli.Journal of bacteriology · 2013Article
- A role for topoisomerase III in Escherichia coli chromosome segregation.Molecular microbiology · 2012Article
- Bacterial topoisomerase I as a target for discovery of antibacterial compounds.Nucleic acids research · 2009Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 4 countries.
Funding
Abstract
Type I DNA topoisomerases are ubiquitous enzymes involved in many aspects of DNA metabolism. Escherichia coli possesses two type I topoisomerase activities, DNA topoisomerase I (Topo I) and III (Topo III). The gene encoding Topo III (topB) can be deleted without affecting cell viability. Cells possessing a deletion of the gene encoding Topo I (topA) are only viable in the presence of an additional compensatory mutation. In the presence of compensatory mutations, Topo I deletion strains grow normally; however, if Topo III activity is repressed in these cells, they filament extensively and possess an abnormal nucleoid structure. These defects can be suppressed by the deletion of the recA gene, suggesting that these enzymes may be involved in RecA-mediated recombination and may specifically resolve recombination intermediates before partitioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.