ArticleProceedings of the National Academy of Sciences of the United States of America2001
Essential role of Drosophila Hdac1 in homeotic gene silencing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 58 citations in OpenAlex.
- The RPD3L deacetylation complex is required for facultative heterochromatin repression inProceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- Loss of histone deacetylase HDAC1 induces cell death in Drosophila epithelial cells through JNK and Hippo signaling.Mechanisms of development · 2016Article
- Polycomb inhibits histone acetylation by CBP by binding directly to its catalytic domain.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Maintenance of Tissue Pluripotency by Epigenetic Factors Acting at Multiple Levels.PLoS genetics · 2016Article
- Histone deacetylase 1 is required for the development of the zebrafish inner ear.Scientific reports · 2016Article
- Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.Development (Cambridge, England) · 2009Article
- Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis.PLoS genetics · 2008Article
- A double-bromodomain protein, FSH-S, activates the homeotic gene ultrabithorax through a critical promoter-proximal region.Molecular and cellular biology · 2007Article
- Functional interaction between the Drosophila knirps short range transcriptional repressor and RPD3 histone deacetylase.The Journal of biological chemistry · 2005Article
- dSAP18 and dHDAC1 contribute to the functional regulation of the Drosophila Fab-7 element.Nucleic acids research · 2005Article
- Regulation of mammalian epithelial differentiation and intestine development by class I histone deacetylases.Molecular and cellular biology · 2004Article
- A 1-megadalton ESC/E(Z) complex from Drosophila that contains polycomblike and RPD3.Molecular and cellular biology · 2003Article
- pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex.Molecular and cellular biology · 2002Article
- Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression.The EMBO journal · 2002Article
- Article
- Polycomb and Trithorax Group Proteins: The Long Road from Mutations in Drosophila to Use in Medicine.Acta naturaeArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deacetylation of the N-terminal tails of core histones plays a crucial role in gene silencing. Rpd3 and Hda1 represent two major types of genes encoding trichostatin A-sensitive histone deacetylases. Although they have been widely found, their cellular and developmental roles remain to be elucidated in metazoa. We show that Drosophila Hdac1, an Rpd3-type gene, interacts cooperatively with Polycomb group repressors in silencing the homeotic genes that are essential for axial patterning of body segments. The biochemical copurification and cytological colocalization of HDAC1 and Polycomb group repressors strongly suggest that HDAC1 is a component of the silencing complex for chromatin modification on specific regulatory regions of homeotic genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.