Interleukin 18: tipping the balance towards a T helper cell 1 response.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

23 citing papers in PubMed.

1. Interleukin-18 armours antitumour immune effectors.Nature reviews. Immunology · 2026
   Review
2. Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.Cancer immunology research · 2024
   Article
3. The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion.Nature communications · 2024
   Article
4. Investigating the Potential Mechanisms and Therapeutic Targets of Inflammatory Cytokines in Post-stroke Depression.Molecular neurobiology · 2024
   Review
5. IL-18 biology in severe asthma.Frontiers in medicine · 2024
   Review
6. NLRP6 negatively regulates host defense against polymicrobial sepsis.Frontiers in immunology · 2024
   Article
7. Interferons-Implications in the Immune Response to Respiratory Viruses.Microorganisms · 2023
   Review
8. Immunologic Role of Innate Lymphoid Cells againstBiomedicines · 2022
   Review
9. Interleukin-18 Binding Protein in Immune Regulation and Autoimmune Diseases.Biomedicines · 2022
   Review
10. Vaccines · 2022
    Article
11. Selective Upregulation of Transcripts for Six Molecules Related to T Cell Costimulation and Phagocyte Recruitment and Activation among 734 Immunity-Related Genes in the Brain during Perforin-Dependent, CD8mSystems · 2020
    Article
12. Foxp3-Positive Regulatory T Cells Contribute to Antifibrotic Effects in Renal Fibrosis via an Interleukin-18 Receptor Signaling Pathway.Frontiers in medicine · 2020
    Article
13. Antitumor and immunomodulatory activities of total flavonoids extract from persimmon leaves in HScientific reports · 2018
    Article
14. HuR Small-Molecule Inhibitor Elicits Differential Effects in Adenomatosis Polyposis and Colorectal Carcinogenesis.Cancer research · 2017
    Article
15. Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization.Cellular & molecular immunology · 2016
    Article
16. Renoprotective Effect of Lactoferrin against Chromium-Induced Acute Kidney Injury in Rats: Involvement of IL-18 and IGF-1 Inhibition.PloS one · 2016
    Article
17. IL-18 contributes to renal damage after ischemia-reperfusion.Journal of the American Society of Nephrology : JASN · 2008
    Article
18. Host-derived interleukin-18 differentially impacts regulatory and conventional T cell expansion during acute graft-versus-host disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2007
    Article
19. Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults.Clinical and experimental immunology · 2006
    Article
20. A method for the generation of standardized qualitative dynamical systems of regulatory networks.Theoretical biology & medical modelling · 2006
    Article

Corrections and comments

• Comment on
  A critical role for interleukin 18 in primary and memory effector responses to Listeria monocytogenes that extends beyond its effects on Interferon gamma production.2001
• Comment on
  Interleukin (IL)-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13.2001

Authors and funding

1 author.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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