ArticleThe Journal of experimental medicine2001
Interleukin (IL)-18 promotes the development of chronic gastrointestinal helminth infection by downregulating IL-13.
Article in The Journal of experimental medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 102 citations in OpenAlex.
- Dietary fibre promotes chronic gut parasite infection via direct and time-dependent modulation of innate immunity.Microbiome · 2026Article
- Chlamydia muridarum Infection Impacts Murine Models of Intestinal Inflammation and Cancer.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025Article
- A Trefoil factor 3-Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection.Mucosal immunology · 2024Article
- The impact of β-glucan on the therapeutic outcome of experimental Trichinella spiralis infection.Parasitology research · 2023Article
- Inflammasome-triggered IL-18 controls skin inflammation in the progression of Buruli ulcer.PLoS pathogens · 2023Article
- The Interactions Between Autoinflammation and Type 2 Immunity: From Mechanistic Studies to Epidemiologic Associations.Frontiers in immunology · 2022Review
- Integrative biology defines novel biomarkers of resistance to strongylid infection in horses.Scientific reports · 2021Article
- Context-dependent roles of B cells during intestinal helminth infection.PLoS neglected tropical diseases · 2021Review
- IFN-γ and IL-18 in conditioned media of parasite-infected host and IL-21-silenced colorectal cancer cells.Experimental and therapeutic medicine · 2021Article
- Cytokines and beyond: Regulation of innate immune responses during helminth infection.Cytokine · 2020Review
- Interleukin-18 in Health and Disease.International journal of molecular sciences · 2019Review
- A Subset of CCL25-Induced Gut-Homing T Cells Affects Intestinal Immunity to Infection and Cancer.Frontiers in immunology · 2019Article
- The Hygiene Hypothesis and Its Inconvenient Truths about Helminth Infections.PLoS neglected tropical diseases · 2016Article
- Allergen-induced interleukin-18 promotes experimental eosinophilic oesophagitis in mice.Immunology and cell biology · 2015Article
- Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis.Clinical immunology (Orlando, Fla.) · 2015Article
- MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Whipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction.Nature genetics · 2014Article
- Trichuris muris research revisited: a journey through time.Parasitology · 2013Review
- IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection.PLoS pathogens · 2013Article
- Trichuris muris: a model of gastrointestinal parasite infection.Seminars in immunopathology · 2012Review
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4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expulsion of the gastrointestinal nematode Trichuris muris is mediated by a T helper (Th) 2 type response involving interleukin (IL)-4 and IL-13. Here we show that Th1 response-associated susceptibility involves prior activation of IL-18 and caspase-1 followed by IL-12 and interferon (IFN)-gamma in the intestine. IL-18-deficient mice are highly resistant to chronic T. muris infection and in vivo treatment of normal mice with recombinant (r)IL-18 suppresses IL-13 and IL-4 secretion but does not affect IFN-gamma. In vivo treatment of T. muris-infected IFN-gamma-deficient mice with rIL-18 demonstrated that the inhibitory effect of IL-18 on IL-13 secretion is independent of IFN-gamma. Hence, IL-18 does not function as an IFN-gamma-inducing cytokine during chronic T. muris infection but rather as a direct regulator of Th2 cytokines. These results provide the first demonstration of the critical role of IL-18 in regulating Th cell responses during gastrointestinal nematode infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.