ArticleThe Journal of cell biology2001
Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b.
Article in The Journal of cell biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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Who cites it
33 citing papers in PubMed, 101 citations in OpenAlex.
- Keratin filaments and soluble vimentin interact with isoform specificity to organize cell signaling.Genes & development · 2026Article
- Shifts in keratin isoform expression activate motility signals during wound healing.Developmental cell · 2024Article
- Keratin isoform shifts modulate motility signals during wound healing.bioRxiv : the preprint server for biology · 2024Article
- Generation of Keratinocytes from Human Induced Pluripotent Stem Cells Under Defined Culture Conditions.Cellular reprogramming · 2021Article
- Pathophysiology of pachyonychia congenita-associated palmoplantar keratoderma: new insights into skin epithelial homeostasis and avenues for treatment.The British journal of dermatology · 2020Review
- A novel deletion in KRT75L4 mediates the frizzle trait in a Chinese indigenous chicken.Genetics, selection, evolution : GSE · 2018Article
- Hair Follicle Terminal Differentiation Is Orchestrated by Distinct Early and Late Matrix Progenitors.Cell reports · 2017Article
- Comparative genomics analyses of alpha-keratins reveal insights into evolutionary adaptation of marine mammals.Frontiers in zoology · 2017Article
- Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.Cell death & disease · 2016Article
- Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75.The Journal of investigative dermatology · 2016Article
- Gene expression profiling in pachyonychia congenita skin.Journal of dermatological science · 2015Article
- Skin fragility and impaired desmosomal adhesion in mice lacking all keratins.The Journal of investigative dermatology · 2014Article
- Keratin gene expression profiles after digit amputation in C57BL/6 vs. regenerative MRL mice imply an early regenerative keratinocyte activated-like state.Physiological genomics · 2013Article
- Comparative anatomy of mouse and human nail units.Anatomical record (Hoboken, N.J. : 2007) · 2013Article
- The expanding significance of keratin intermediate filaments in normal and diseased epithelia.Current opinion in cell biology · 2013Review
- Cytokeratin 18 is not required for morphogenesis of developing prostates but contributes to adult prostate regeneration.BioMed research international · 2013Article
- Progress towards genetic and pharmacological therapies for keratin genodermatoses: current perspective and future promise.Experimental dermatology · 2012Review
- Bmp signalling in filiform tongue papillae development.Archives of oral biology · 2012Article
- Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders.The Journal of investigative dermatology · 2012Article
- Novel molecular therapies for heritable skin disorders.The Journal of investigative dermatology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The murine genome is known to have two keratin 6 (K6) genes, mouse K6 (MK6)a and MK6b. These genes display a complex expression pattern with constitutive expression in the epithelia of oral mucosa, hair follicles, and nail beds. We generated mice deficient for both genes through embryonic stem cell technology. The majority of MK6a/b-/- mice die of starvation within the first two weeks of life. This is due to a localized disintegration of the dorsal tongue epithelium, which results in the build up of a plaque of cell debris that severely impairs feeding. However, approximately 25% of MK6a/b-/- mice survive to adulthood. Remarkably, the surviving MK6a/b-/- mice have normal hair and nails. To our surprise, we discovered MK6 staining both in the hair follicle and the nail bed of MK6a/b-/- mice, indicating the presence of a third MK6 gene. We cloned this previously unknown murine keratin gene and found it to be highly homologous to human K6hf, which is expressed in hair follicles. We therefore termed this gene MK6 hair follicle (MK6hf). The presence of MK6hf in the MK6a/b-/- follicles and nails offers an explanation for the absence of hair and nail defects in MK6a/b-/- animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.