ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Increasing the number of synapses modifies olfactory perception in Drosophila.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
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- Associative Learning Requires Neurofibromin to Modulate GABAergic Inputs to Drosophila Mushroom Bodies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposit formation.Molecular biology of the cell · 2020Article
- Temporally specific engagement of distinct neuronal circuits regulating olfactory habituation ineLife · 2018Article
- Brain Mapping and Synapse QuantificationFrontiers in neuroanatomy · 2017Article
- The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.Molecular and cellular therapies · 2016Review
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- In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndrome.Frontiers in cellular neuroscience · 2015Article
- Synaptic organization of the Drosophila antennal lobe and its regulation by the Teneurins.eLife · 2014Article
- Flies dynamically anti-track, rather than ballistically escape, aversive odor during flight.The Journal of experimental biology · 2012Article
- Central adaptation to odorants depends on PI3K levels in local interneurons of the antennal lobe.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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- Calcium-stores mediate adaptation in axon terminals of olfactory receptor neurons in Drosophila.BMC neuroscience · 2011Article
- Synapse loss in olfactory local interneurons modifies perception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Macroglomeruli for fruit odors change blend preference in Drosophila.Die Naturwissenschaften · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila mutant gigas produces an enlargement of postmitotic cells caused by additional rounds of DNA replication. In neurons, the mutant cell establishes more synapses than normal. We have taken advantage of this feature to study the effect of synapse number on odorant perception. Mosaic adults were generated in which one antenna was homozygous for gigas, whereas the contralateral side served as an internal control. Morphological analysis indicates that the number and type of sensory afferents forming the mutant antenna, as well as their projection to the olfactory glomeruli, are normal. In contrast, the volume of identified glomeruli increases to a variable extent, and mutant sensory neurons branch profusely. The number of synapses, estimated in the ventral (V) glomerulus that receives ipsilateral afferents only, is increased twofold to threefold. Large-dense-core vesicle-containing terminals that probably modulate olfactory centers are identified in the V glomerulus. Their number and size are not modified by the mutant input. Sensory transduction, measured by electroantennograms, is normal in amplitude and kinetics. In odorant tests, however, the profile of the behavioral response to ethyl acetate shows attractive responses to concentrations to which sibling controls remain indifferent (10(-)8 and 10(-)7 v/v). In addition, the intensity of the response is augmented both at attractive and repulsive odorant concentrations with respect to that of controls. These results demonstrate that increased synapse number in the sensory neurons can modify the behavior of the organism, allowing a higher sensitivity of perception.
Indexed as
Identifiers
11487649PMC6763191W2129141075What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.