ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2001
Gating and braking of short- and long-term modulatory effects by interactions between colocalized neuromodulators.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
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- Distinct Co-Modulation Rules of Synapses and Voltage-Gated Currents Coordinate Interactions of Multiple Neuromodulators.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Substrates for Neuronal Cotransmission With Neuropeptides and Small Molecule Neurotransmitters inFrontiers in cellular neuroscience · 2018Review
- General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.Frontiers in neural circuits · 2018Review
- Scaling Our World View: How Monoamines Can Put Context Into Brain Circuitry.Frontiers in cellular neuroscience · 2018Article
- The Lesioned Spinal Cord Is a "New" Spinal Cord: Evidence from Functional Changes after Spinal Injury in Lamprey.Frontiers in neural circuits · 2017Review
- Neuromodulated Spike-Timing-Dependent Plasticity, and Theory of Three-Factor Learning Rules.Frontiers in neural circuits · 2015Review
- Article
- Synaptic Variability Introduces State-Dependent Modulation of Excitatory Spinal Cord Synapses.Neural plasticity · 2015Article
- PKC-mediated GABAergic enhancement of dopaminergic responses: implication for short-term potentiation at a dual-transmitter synapse.Journal of neurophysiology · 2014Article
- A synaptic mechanism for network synchrony.Frontiers in cellular neuroscience · 2014Review
- Removing sensory input disrupts spinal locomotor activity in the early postnatal period.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2013Article
- Neuropeptide modulation of microcircuits.Current opinion in neurobiology · 2012Review
- Beyond the wiring diagram: signalling through complex neuromodulator networks.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Modulation of motor behavior by dopamine and the D1-like dopamine receptor AmDOP2 in the honey bee.Journal of insect physiology · 2010Article
- Shared Strategies for Behavioral Switching: Understanding How Locomotor Patterns are Turned on and Off.Frontiers in behavioral neuroscience · 2010Article
- Parallel regulation of a modulator-activated current via distinct dynamics underlies comodulation of motor circuit output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Metamodulation of a spinal locomotor network by nitric oxide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Loss of flight and associated neuronal rhythmicity in inositol 1,4,5-trisphosphate receptor mutants of Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Endogenous dopamine maintains synchronous oscillation of intracellular calcium in primary cultured-mouse midbrain neurons.Cellular and molecular neurobiology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Spinal locomotor networks in the lamprey are modulated by tachykinin neuropeptides. A single 10 min application of the tachykinin substance P evokes a short-term ( approximately 1 hr) presynaptic facilitation of glutamate release and the postsynaptic potentiation of NMDA responses. The latter effect induces a long-term (>24 hr) protein synthesis-dependent increase in the frequency of network activity. Tachykinins are contained in a ventromedial spinal plexus into which the medial dendrites of network neurons project. Neurons in this plexus also contain colocalized dopamine and 5-HT. Here, dynamic plasticity evoked by modulator interactions has been examined by investigating the effects of 5-HT and dopamine on specific cellular, synaptic, and network effects of substance P. Preapplied 5-HT blocked the substance P-mediated increase in the network burst frequency and the potentiation of NMDA-evoked cellular responses that underlies its induction. 5-HT also blocked the presynaptic facilitation of glutamatergic synaptic transmission by substance P. The presynaptic, but not postsynaptic, effect of 5-HT was reduced by the protein phosphatase 2B inhibitor cypermethrin. Dopamine did not directly modulate the effects of substance P. However, it reduced the presynaptic interactive effect of 5-HT and thus gated the presynaptic potentiation of glutamatergic inputs by substance P. However, the substance P-mediated potentiation of NMDA responses was not gated by dopamine, and thus the long-term network modulation was not induced. Neuromodulator effects and their interactions can thus be modulated. By selecting components from the modulatory repertoire of substance P, these interactions evoke dynamic changes in short- and long-term synaptic and network plasticity.
Indexed as
Identifiers
11487621PMC6763193W1483515847What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.