ArticleBritish journal of pharmacology2001
Functional characterization of coronary vascular adenosine receptors in the mouse.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 59 citations in OpenAlex.
- Reduced adenosine receptor expression in ACS patients with no-reflow phenomenon undergoing primary PCI.Future cardiology · 2025Article
- Comparative assessment of coronary physiology using transthoracic pulsed-wave Doppler and myocardial contrast echocardiography in rats.European radiology experimental · 2023Article
- Adenosine and Its Receptors: An Expected Tool for the Diagnosis and Treatment of Coronary Artery and Ischemic Heart Diseases.International journal of molecular sciences · 2020Review
- Aldosterone impairs coronary adenosine-mediated vasodilation via reduced functional expression of CaAmerican journal of physiology. Heart and circulatory physiology · 2019Article
- Paradoxical arteriole constriction compromises cytosolic and mitochondrial oxygen delivery in the isolated saline-perfused heart.American journal of physiology. Heart and circulatory physiology · 2018Article
- Adenosine Receptors As Drug Targets for Treatment of Pulmonary Arterial Hypertension.Frontiers in pharmacology · 2017Review
- Enhanced A2A adenosine receptor-mediated increase in coronary flow in type I diabetic mice.Journal of molecular and cellular cardiology · 2016Article
- Involvement of NADPH oxidase in A2A adenosine receptor-mediated increase in coronary flow in isolated mouse hearts.Purinergic signalling · 2015Article
- Cardiac purinergic signalling in health and disease.Purinergic signalling · 2015Review
- Evidence for the involvement of NADPH oxidase in adenosine receptors-mediated control of coronary flow using APhysiological reports · 2013Article
- The adenosine A₂A receptor - myocardial protectant and coronary target in endotoxemia.International journal of cardiology · 2013Article
- An allosteric modulator of the adenosine A1 receptor improves cardiac function following ischaemia in murine isolated hearts.Pharmaceuticals (Basel, Switzerland) · 2013Article
- Contributions of A2A and A2B adenosine receptors in coronary flow responses in relation to the KATP channel using A2B and A2A/2B double-knockout mice.American journal of physiology. Heart and circulatory physiology · 2011Article
- Contribution of adenosine A(2A) and A(2B) receptors to ischemic coronary dilation: role of K(V) and K(ATP) channels.Microcirculation (New York, N.Y. : 1994) · 2010Article
- Adenosine A2A receptor signaling regulation of cardiac NADPH oxidase activity.Free radical biology & medicine · 2008Article
- Effects of isoflurane on coronary blood flow velocity in young, old and ApoE(-/-) mice measured by Doppler ultrasound.Ultrasound in medicine & biology · 2007Article
- Contractile effects of adenosine, coronary flow and perfusion pressure in murine myocardium.Pflugers Archiv : European journal of physiology · 2007Article
- Oxidant stress and damage in post-ischemic mouse hearts: effects of adenosine.Molecular and cellular biochemistry · 2006Article
- Adenosine concentration in the porcine coronary artery wall and A2A receptor involvement in hypoxia-induced vasodilatation.The Journal of physiology · 2006Article
- Differential coronary microvascular exchange responses to adenosine: roles of receptor and microvessel subtypes.Microcirculation (New York, N.Y. : 1994) · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary responses to adenosine agonists were assessed in perfused mouse and rat hearts. The roles of nitric oxide (NO) and ATP-dependent K(+) channels (K(ATP)) were studied in the mouse. Resting coronary resistance was lower in mouse vs rat, as was minimal resistance (2.2+/-0.1 vs 3.8+/-0.2 mmHg ml(-1) min(-1) g(-1)). Peak hyperaemic flow after 20 - 60 s occlusion was greater in mouse. Adenosine agonists induced coronary dilation in mouse, with pEC(50)s of 9.4+/-0.1 for 2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethyl carboxamidoadenosine (CGS21680, A(2A)-selective agonist), 9.3+/-0.1 for 5'-N-ethylcarboxamidoadenosine (NECA, A(1)/A(2) agonist), 8.4+/-0.1 for 2-chloroadenosine (A(1)/A(2) agonist), 7.7+/-0.1 for N(6)-(R)-(phenylisopropyl)adenosine (R-PIA, A(1)/A(2B) selective), and 6.8+/-0.2 for adenosine. The potency order (CGS21680=NECA>2-chloroadenosine>R-PIA>adenosine) supports A(2A) adenosine receptor-mediated dilation in mouse coronary vessels. 0.2 - 2 microM of the A(2B)-selective antagonist alloxazine failed to alter CGS21680 or 2-chloroadenosine responses. pEC(50)s in rat were 6.7+/-0.2 for CGS21680, 7.3+/-0.1 for NECA, 7.6+/-0.1 for 2-chloroadenosine, 7.2+/-0.1 for R-PIA, and 6.2+/-0.1 for adenosine (2-chloroadenosine>NECA=R-PIA>CGS21680> adenosine), supporting an A(2B) adenosine receptor response. NO-synthase antagonism with 50 microM N(G)-nitro L-arginine (L-NOARG) increased resistance by approximately 25%, and inhibited responses to CGS21680 (pEC(50)=9.0+/-0.1), 2-chloroadenosine (pEC(50)=7.3+/-0.2) and endothelial-dependent ADP, but not sodium nitroprusside (SNP). K(ATP) channel blockade with 5 microM glibenclamide increased resistance by approximately 80% and inhibited responses to CGS21680 in control (pEC(50)=8.3+/-0.1) and L-NOARG-treated hearts (pEC(50)=7.3+/-0.1), and to 2-chloroadenosine in control (pEC(50)=6.7+/-0.1) and L-NOARG-treated hearts (pEC(50)=5.9+/-0.2). In summary, mouse coronary vessels are more sensitive to adenosine than rat vessels. A(2A) adenosine receptors mediate dilation in mouse coronary vessels vs A(2B) receptors in rat. Responses in the mouse involve a sensitive NO-dependent response and K(ATP)-dependent dilation.
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