ArticleBritish journal of pharmacology2001
Pharmacological characterization of muscarinic receptors in mouse isolated urinary bladder smooth muscle.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 41 citations in OpenAlex.
- L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle.PloS one · 2014Article
- Functional significance of muscarinic receptor expression within the proximal and distal rat vagina.American journal of physiology. Regulatory, integrative and comparative physiology · 2009Article
- In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder.British journal of pharmacology · 2009Article
- The use of occupation isoboles for analysis of a response mediated by two receptors: M2 and M3 muscarinic receptor subtype-induced mouse stomach contractions.The Journal of pharmacology and experimental therapeutics · 2008Article
- Interactions between drugs and occupied receptors.Pharmacology & therapeutics · 2007Review
- Pharmacodynamics of propiverine and three of its main metabolites on detrusor contraction.British journal of pharmacology · 2005Article
- The M2 muscarinic receptor mediates in vitro bladder contractions from patients with neurogenic bladder dysfunction.American journal of physiology. Regulatory, integrative and comparative physiology · 2004Article
- Gender comparison of muscarinic receptor expression and function in rat and human urinary bladder: differential regulation of M2 and M3 receptors?Naunyn-Schmiedeberg's archives of pharmacology · 2003Article
- Muscarinic receptors in isolated urinary bladder smooth muscle from different mouse strains.British journal of pharmacology · 2002Article
- M(3) muscarinic receptors mediate contraction of human urinary bladder.British journal of pharmacology · 2002Article
- Pharmacological characterization of muscarinic receptors in mouse isolated urinary bladder smooth muscle.British journal of pharmacology · 2001Article
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Authors and funding
2 authors at 2 institutions in 1 country.
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Abstract
The pharmacological characteristics of muscarinic receptors in the male mice urinary bladder smooth muscle were studied. (+)-Cis-dioxolane, oxotremorine-M, acetylcholine, carbachol and pilocarpine induced concentration-dependent contractions of the urinary bladder smooth muscle (pEC(50)=6.6+/-0.1, 6.9+/-0.1, 6.7+/-0.1, 5.8+/-0.1 and 5.8+/-0.1, E(Max)=3.2+/-0.8 g, 2.7+/-0.4 g, 1.0+/-0.1 g, 2.7+/-0.3 and 0.9+/-0.2 g, respectively, n=4). These contractions were competitively antagonized by a range of muscarinic receptor antagonists (pK(B) values): atropine (9.22+/-0.09), pirenzepine (6.85+/-0.08), 4-DAMP (8.42+/-0.14), methoctramine (5.96+/-0.05), p-F-HHSiD (7.48+/-0.09), tolterodine (8.89+/-0.13), AQ-RA 741 (7.04+/-0.12), s-secoverine (8.21+/-0.09), zamifenacin (8.30+/-0.17) and darifenacin (8.70+/-0.09). In this tissue, the pK(B) values correlated most favourably with pK(i) values for these compounds at human recombinant muscarinic M(3) receptors. A significant correlation was also noted at human recombinant muscarinic m5 receptors given the poor discriminative ability of ligands between M(3) and m5 receptors. In recontraction studies, in which the muscarinic M(3) receptor population was decreased, and conditions optimized to study M(2) receptor activation, methoctramine exhibited an affinity estimate consistent with muscarinic M(3) receptors (pK(B)=6.23+/-0.14; pA(2)=6.16+/-0.03). Overall, these data study suggest that muscarinic M(3) receptors are the predominant, if not the exclusive, subtype mediating contractile responses to muscarinic agonists in male mouse urinary bladder smooth muscle.
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