ArticleBritish journal of pharmacology2001
The anti-migraine 5-HT(1B/1D) agonist rizatriptan inhibits neurogenic dural vasodilation in anaesthetized guinea-pigs.
Article in British journal of pharmacology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Synthesis of sulfanyl derivatives of 1,2,4-triazolesRSC advances · 2026Article
- Dopamine and prolactin in migraine: Mechanisms and potential therapeutic targets.Journal of neuroendocrinology · 2025Review
- Intra-arterial lidocaine administration of lidocaine in middle meningeal artery for short-term treatment of subarachnoid hemorrhage-related headaches.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Meningeal brain borders and migraine headache genesis.Trends in neurosciences · 2024Review
- The 5-HTNature reviews. Neurology · 2023Review
- Synthesis, Kinetics, Binding Conformations and Structure-activity Relationship of Potent Tyrosinase Inhibitors: Aralkylated 2-aminothiazole-ethyltriazole Hybrids.Iranian journal of pharmaceutical research : IJPR · 2021Article
- Effects of monoclonal antagonist antibodies on calcitonin gene-related peptide receptor function and trafficking.The journal of headache and pain · 2019Article
- Targeting the central projection of the dural trigeminovascular system for migraine prophylaxis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- CGRP in Animal Models of Migraine.Handbook of experimental pharmacology · 2019Review
- Effect of intra-arterial injection of lidocaine and methyl-prednisolone into middle meningeal artery on intractable headaches.Journal of vascular and interventional neurology · 2014Article
- Modelling headache and migraine and its pharmacological manipulation.British journal of pharmacology · 2014Review
- 5-HT7 receptors are involved in neurogenic dural vasodilatation in an experimental model of migraine.Journal of molecular neuroscience : MN · 2014Article
- Alum catalyzed simple, efficient, and green synthesis of 2-[3-amino-5-methyl-5-(pyridin-3-yl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]propanoic acid derivatives in aqueous media.TheScientificWorldJournal · 2013Article
- Pharmacology.Handbook of clinical neurology · 2010Article
- Activation of iGluR5 kainate receptors inhibits neurogenic dural vasodilatation in an animal model of trigeminovascular activation.British journal of pharmacology · 2009Article
- Inhibitory effect of BIBN4096BS, CGRP(8-37), a CGRP antibody and an RNA-Spiegelmer on CGRP induced vasodilatation in the perfused and non-perfused rat middle cerebral artery.British journal of pharmacology · 2007Article
- Rizatriptan in the treatment of migraine.Neuropsychiatric disease and treatment · 2006Article
- Topiramate inhibits trigeminovascular activation: an intravital microscopy study.British journal of pharmacology · 2005Article
- Characterization of opioid receptors that modulate nociceptive neurotransmission in the trigeminocervical complex.British journal of pharmacology · 2003Article
- Spotlight on rizatriptan in migraine.CNS drugs · 2002Review
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4 authors at 1 institution in 1 country.
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Abstract
These studies investigated the pharmacology of neurogenic dural vasodilation in anaesthetized guinea-pigs. Following introduction of a closed cranial window the meningeal (dural) blood vessels were visualized using intravital microscopy and the diameter constantly measured using a video dimension analyser. Dural blood vessels were constricted with endothelin-1 (3 microg kg(-1), i.v.) prior to dilation of the dural blood vessels with calcitonin gene-related peptide (CGRP; 1 microg kg(-1), i.v.) or local electrical stimulation (up to 300 microA) of the dura mater. In guinea-pigs pre-treated with the CGRP receptor antagonist CGRP((8-37)) (0.3 mg kg(-1), i.v.) the dilator response to electrical stimulation was inhibited by 85% indicating an important role of CGRP in neurogenic dural vasodilation in this species. Neurogenic dural vasodilation was also blocked by the 5-HT(1B/1D) agonist rizatriptan (100 microg kg(-1)) with estimated plasma levels commensurate with concentrations required for anti-migraine efficacy in patients. Rizatriptan did not reverse the dural dilation evoked by CGRP indicating an action on presynaptic receptors located on trigeminal sensory fibres innervating dural blood vessels. In addition, neurogenic dural vasodilation was also blocked by the selective 5-HT(1D) agonist PNU-142633 (100 microg kg(-1)) but not by the 5-HT(1F) agonist LY334370 (3 mg kg(-1)) suggesting that rizatriptan blocks neurogenic vasodilation via an action on 5-HT(1D) receptors located on perivascular trigeminal nerves to inhibit CGRP release. This mechanism may underlie one of the anti-migraine actions of the triptan class exemplified by rizatriptan and suggests that the guinea-pig is an appropriate species in which to investigate the pharmacology of neurogenic dural vasodilation.
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