ReviewCurrent atherosclerosis reports2001
Did the antioxidant trials fail to validate the oxidation hypothesis?
Review in Current atherosclerosis reports, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Effects of short-term atorvastatin use in patients with calcium stones: A randomized placebo-controlled clinical trial.Investigative and clinical urology · 2019Trial
- Dysregulated Redox Signaling and Its Impact on Inflammatory Pathways, Mitochondrial Dysfunction, Autophagy and Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- Unusual Bioactive Compounds with Antioxidant Properties in Adjuvant Therapy Supporting Cognition Impairment in Age-Related Neurodegenerative Disorders.International journal of molecular sciences · 2021Review
- Targeting vascular (endothelial) dysfunction.British journal of pharmacology · 2017Review
- N-acetylcysteine inhibits in vivo oxidation of native low-density lipoprotein.Scientific reports · 2015Article
- AGE restriction in diabetes mellitus: a paradigm shift.Nature reviews. Endocrinology · 2011Review
- Oxidized low-density lipoprotein.Methods in molecular biology (Clifton, N.J.) · 2010Review
- The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells.Journal of medicinal food · 2009Article
- Alpha-tocopherol is ineffective in preventing the decomposition of preformed lipid peroxides and may promote the accumulation of toxic aldehydes: a potential explanation for the failure of antioxidants to affect human atherosclerosis.Antioxidants & redox signaling · 2009Article
- Antioxidants and cardiovascular disease: Still a topic of interest.Environmental health and preventive medicine · 2004Article
- The Jeremiah Metzger Lecture. Pathogenesis of atherosclerosis: redox as a unifying mechanism.Transactions of the American Clinical and Climatological Association · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconceptions about the hypothesis and unjustified outcome expectations. Wrong selection of patient population, endpoints that are incompatible with the hypothesis, poor choice of antioxidants, and lack of inclusion of biochemical markers of oxidative stress and markers of vascular response are some of the contributors to the "failure" of these trials.
Indexed as
Identifiers
11487450What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.