ArticleBritish journal of cancer2001
In vivo evaluation of the early events associated with liver metastasis of circulating cancer cells.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
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- Development of a perfusable, hierarchical microvasculature-on-a-chip model.Lab on a chip · 2023Article
- Beneficial Effect of Fluoxetine and Sertraline on Chronic Stress-Induced Tumor Growth and Cell Dissemination in a Mouse Model of Lymphoma: Crucial Role of Antitumor Immunity.Frontiers in immunology · 2018Article
- Metastasis of circulating tumor cells: favorable soil or suitable biomechanics, or both?Cell adhesion & migration · 2015Review
- Differential arrest and adhesion of tumor cells and microbeads in the microvasculature.Biomechanics and modeling in mechanobiology · 2014Article
- β-carotene Regulates the Murine Liver Microenvironment of a Metastatic Neuroblastoma.Journal of cancer prevention · 2013Article
- CXCR4/CXCL12 participate in extravasation of metastasizing breast cancer cells within the liver in a rat model.PloS one · 2012Article
- Metastatic tumor cell arrest in the liver-lumen occlusion and specific adhesion are not exclusive.International journal of colorectal disease · 2009Article
- The metastatic niche: adapting the foreign soil.Nature reviews. Cancer · 2009Review
- Genome-wide discovery of functional transcription factor binding sites by comparative genomics: the case of Stat3.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Functional blocking of specific integrins inhibit colonic cancer migration.Clinical & experimental metastasis · 2009Article
- An in vivo rat model for early development of colorectal cancer metastasis to liver.International journal of experimental pathology · 2008Article
- Heterogeneity of drug target expression among metastatic lesions: lessons from a breast cancer autopsy program.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- In vivo models for early development of colorectal liver metastasis.International journal of experimental pathology · 2008Review
- The tumor cell-host organ interface in the early onset of metastatic organ colonisation.Clinical & experimental metastasis · 2008Review
- A bioreactor model of mouse tumor progression.Journal of biomedicine & biotechnology · 2007Article
- Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3-/- mice.Oncogene · 2006Article
- Enhanced green fluorescent protein-transfection of murine colon carcinoma cells: key for early tumor detection and quantification.Clinical & experimental metastasis · 2003Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism of metastasis formation remains still largely unknown. Many studies underline the importance and complexity of the initial arrest of the circulating tumour cells in the target organ, a key stage in metastasis occurrence. In our study, we evaluated by visual means the metastasis formation using an in vivo microscopy system in a murine model. Moreover, we investigated the involvement of P-selectin in these processes using immunohistochemistry and P-selectin knockout mice. The present study offers direct evidence of distinct pathways for tumour metastasis formation by a lymphoma cell - EL-4 and a solid tumour cell - C26. Off-line analysis of the images and histological data confirmed that mechanical entrapment of the solid tumour cell, which had a bigger diameter than that of the liver sinusoids, promoted metastasis without any detectable involvement of adhesion molecules. On the other hand, we observed that lymphoma cells, in spite of their smaller diameter as compared to the sinusoids, promoted liver metastasis as well, but with the essential participation in their arrest of P-selectin, indicating an adhesion molecule-mediated pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.