ArticleBritish journal of cancer2001
HPV presence precedes abnormal cytology in women developing cervical cancer and signals false negative smears.
Article in British journal of cancer, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Identification of Circulating MicroRNAs as a Promising Diagnostic Biomarker for Cervical Intraepithelial Neoplasia and Early Cancer: A Meta-Analysis.BioMed research international · 2020Pooled it
- Extended duration of the detectable stage by adding HPV test in cervical cancer screening.British journal of cancer · 2003Trial
- Epidemiology of high-risk human papillomavirus among women of the north-central region of Ecuador: a retrospective study.Infectious agents and cancer · 2025Article
- HPV infection and its correlation with p53 and Bcl-2 among pregnant mothers and their infants.Virus genes · 2024Article
- Anal Cancer and Anal Intraepithelial Neoplasia Risk among Patients Treated for HPV-Related Gynecological Diseases-A Systematic Review.Journal of clinical medicine · 2023Review
- Cytology interpretation after a change to HPV testing in primary cervical screening: Observational study from the English pilot.Cancer cytopathology · 2022Observational
- Proteases and HPV-Induced Carcinogenesis.Cancers · 2022Review
- False Negative Results in Cervical Cancer Screening-Risks, Reasons and Implications for Clinical Practice and Public Health.Diagnostics (Basel, Switzerland) · 2022Review
- Human papilloma virus (HPV) profiles in breast cancer: future management.Annals of translational medicine · 2020Review
- Key Molecular Events in Cervical Cancer Development.Medicina (Kaunas, Lithuania) · 2019Review
- The promising role of PAX1 (aliases: HUP48, OFC2) gene methylation in cancer screening.Molecular genetics & genomic medicine · 2019Review
- Identification of reference genes for circulating long noncoding RNA analysis in serum of cervical cancer patients.FEBS open bio · 2018Article
- Molecular progression to cervical precancer, epigenetic switch or sequential model?International journal of cancer · 2018Article
- Long non-coding RNA H19 enhances cell proliferation and anchorage-independent growth of cervical cancer cell lines.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis.Oncogene · 2013Article
- Spectral cytopathology of cervical samples: detecting cellular abnormalities in cytologically normal cells.Laboratory investigation; a journal of technical methods and pathology · 2010Article
- Human papillomavirus (HPV) infection and intraepithelial neoplasia and invasive cancer of the uterine cervix: a case-control study in Zaragoza, Spain.Infectious agents and cancer · 2008Article
- Preferential risk of HPV16 for squamous cell carcinoma and of HPV18 for adenocarcinoma of the cervix compared to women with normal cytology in The Netherlands.British journal of cancer · 2006Article
- Human papillomavirus infection in women who develop high-grade cervical intraepithelial neoplasia or cervical cancer: a case-control study in the UK.British journal of cancer · 2005Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a retrospective case-control study, we investigated high-risk HPV DNA presence by general primer GP5+/6+ PCR in the last normal cervical smear in the patient archives (i.e. baseline smear) of 57 women who later developed cervical cancer. Also, normal cervical smears of 114 age-matched control women were analysed. High-risk HPV DNA was detected in 37 of the 57 (65%) baseline smears of the case women, and 7 (6%) of 114 smears of the control women (OR 28, 95% Cl 11-72). The HPV positive subsequent smears and cervical cancer biopsies of the case women contained the same HPV type as was detected in the baseline smear. After cytological revision, the baseline smears of 48 case women (84%) were reclassified as abnormal, 33 (69%) of which scored high-risk HPV DNA positive. Ultimately, an undisputable normal baseline smear was found in only 10 case women. In 7 (70%) of them this smear was HPV positive, whereas only 7 (7%) of 104 revised, undisputable normal smears of control women were high-risk HPV positive (OR 32, 95% Cl 6.8-153). The results showed that (1) high-risk HPV presence precedes abnormal cytology in women who develop cervical cancer, and (2) high-risk HPV testing signals false-negative smears of women at risk of cervical cancer.
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