ArticleThe Journal of biological chemistry2001
Identification of a new form of death-associated protein kinase that promotes cell survival.
Article in The Journal of biological chemistry, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 59 citations in OpenAlex.
- Candidate Genes Associated with Survival Following Highly Pathogenic Avian Influenza Infection in Chickens.International journal of molecular sciences · 2024Article
- Expression and Functional Relevance of Death-Associated Protein Kinase in Human Drug-Resistant Epileptic Brain: Focusing on the Neurovascular Interface.Molecular neurobiology · 2019Article
- Death-Associated Protein Kinase 1 as a Promising Drug Target in Cancer and Alzheimer's Disease.Recent patents on anti-cancer drug discovery · 2019Review
- Drak Is Required for Actomyosin Organization During Drosophila Cellularization.G3 (Bethesda, Md.) · 2016Article
- Demethylation restores SN38 sensitivity in cells with acquired resistance to SN38 derived from human cervical squamous cancer cells.Oncology reports · 2012Article
- Delta-like 1-Lysine613 regulates notch signaling.Biochimica et biophysica acta · 2011Article
- Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis.The Journal of biological chemistry · 2010Article
- Post-translational modification of cyclin A1 is associated with staurosporine and TNFalpha induced apoptosis in leukemic cells.Molecular and cellular biochemistry · 2009Article
- Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.The Journal of biological chemistry · 2007Article
- Control of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation.The Journal of biological chemistry · 2006Article
- Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase.Archives of biochemistry and biophysics · 2006Article
- Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.Gastroenterology · 2005Article
- Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK.The EMBO journal · 2005Article
- Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions.Molecular and cellular biology · 2004Article
- Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts.The Journal of cell biology · 2004Article
- Antisense depletion of death-associated protein kinase promotes apoptosis.The Journal of biological chemistry · 2003Article
- A death-associated protein kinase (DAPK)-interacting protein, DIP-1, is an E3 ubiquitin ligase that promotes tumor necrosis factor-induced apoptosis and regulates the cellular levels of DAPK.The Journal of biological chemistry · 2002Article
- DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
In this study, two alternatively spliced forms of the mouse death-associated protein kinase (DAPK) have been identified and their roles in apoptosis examined. The mouse DAPK-alpha sequence is 95% identical to the previously described human DAPK, and it has a kinase domain and calmodulin-binding region closely related to the 130-150 kDa myosin light chain kinases. A 12-residue extension of the carboxyl terminus of DAPK-beta distinguishes it from the human and mouse DAPK-alpha. DAPK phosphorylates at least one substrate in vitro and in vivo, the myosin II regulatory light chain. This phosphorylation occurs preferentially at Ser-19 and is stimulated by calcium and calmodulin. The mRNA encoding DAPK is widely distributed and detected in mouse embryos and most adult tissues, although the expression of the encoded 160-kDa DAPK protein is more restricted. Overexpression of DAPK-alpha, the mouse homolog of human DAPK has a negligible effect on tumor necrosis factor (TNF)-induced apoptosis. Overexpression of DAPK-beta has a strong cytoprotective effect on TNF-treated cells. Biochemical analysis of TNF-treated cell lines expressing mouse DAPK-beta suggests that the cytoprotective effect of DAPK is mediated through both intrinsic and extrinsic apoptotic signaling pathways and results in the inhibition of cytochrome c release from the mitochondria as well as inhibition of caspase-3 and caspase-9 activity. These results suggest that the mouse DAPK-beta is a negative regulator of TNF-induced apoptosis.
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