ArticleThe American journal of pathology2001
Adenomyosis--a result of disordered stromal differentiation.
Article in The American journal of pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 138 citations in OpenAlex.
- The interaction between inflammation and estrogen in adenomyosis : from molecular mechanisms to therapeutic strategies.Seminars in immunopathology · 2026Review
- Three-dimensional characterization of adenomyosis in female mice: Toward a novel system for drug efficacy evaluation.Journal of the Endocrine Society · 2026Article
- Hyperestrogenic imprinting and developmental origins of endometriosis and adenomyosis.Human reproduction open · 2026Article
- Nociceptive Nerve-Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140bAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Temporal dynamics of uterine immune microenvironment remodeling in a murine model of adenomyosis.Molecular human reproduction · 2025Article
- Lipidome atlas of human myometrium reveals distinctive lipid signatures associated with adenomyosis: Combination of high-coverage lipidomics and mass spectrometry imaging.Journal of pharmaceutical analysis · 2025Article
- Decreased expression of Syndecan- 1 (CD138) in the endometrium of adenomyosis patients suggests a potential pathogenetic role.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Impaired fertility in adenomyosis: a murine model reveals endometrial receptivity and progesterone resistance imbalances.Reproduction (Cambridge, England) · 2024Article
- Adenomyotic Lesions Are Induced in the Mouse Uterus after Exposure to NSAID and EE2 Mixtures at Environmental Doses.International journal of molecular sciences · 2024Article
- Shorter Anogenital Distance in Women with Ovarian Endometriomas and Adenomyosis, but Not Uterine Leiomyomas.Biomedicines · 2023Article
- MIR503HG silencing promotes endometrial stromal cell progression and metastasis and suppresses apoptosis in adenomyosis by activating the Wnt/β‑catenin pathway via targeting miR‑191.Experimental and therapeutic medicine · 2023Article
- Estrogen-increased SGK1 Promotes Endometrial Stromal Cell Invasion in Adenomyosis by Regulating with LPAR2.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Pre-clinical models to study abnormal uterine bleeding (AUB).EBioMedicine · 2022Review
- Transcriptome analysis of eutopic endometrial stromal cells in women with adenomyosis by RNA-sequencing.Bioengineered · 2022Article
- Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice.International journal of molecular sciences · 2022Article
- Unveiling the Pathogenesis of Adenomyosis through Animal Models.Journal of clinical medicine · 2022Review
- Analysis of the Mechanism of GuizhiFuling Wan in Treating Adenomyosis Based on Network Pharmacology Combined with Molecular Docking and Experimental Verification.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Celecoxib reduces inflammation and angiogenesis in mice with adenomyosis.American journal of translational research · 2021Article
- Mode Switch of CaFrontiers in physiology · 2021Article
- The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis.Frontiers in physiology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adenomyosis is a fairly frequent disorder in adult women characterized by the haphazard location of endometrial glands and stroma deep within the myometrium of the uterus. This study compared the effects on uterine development of the selective estrogen receptor modulators, tamoxifen, toremifene, and raloxifene with estradiol when given orally to female mice on days 2 to 5 after birth. Uterine adenomyosis was found in all (14 of 14) mice dosed with tamoxifen and most mice (12 of 14) treated with toremifene, but in none of the vehicle-dosed controls, in only one animal treated with raloxifene at 42 and 90 days after dosing and in none of the mice treated with estradiol at 42 days. At 6 days, the uterus in the groups that developed a high incidence of adenomyosis showed histological evidence of disturbed differentiation of the myometrium. Gene-expression XY-scatterplots using Clontech mouse 1.2 Atlas mouse cDNA expression arrays analyzing total uterine RNA showed nerve growth factor-alpha, preadipocyte factor-1, and insulin-like growth factor-2 were key genes differentially modified by tamoxifen or toremifene treatment, relative to the controls. As these genes may play an important role in regulating differentiation and development of the myometrium, these data suggest that adenomyosis may be caused primarily by defects in the formation of the myometrium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.