ArticleThe Journal of physiology2001
Measurement of chloride flux associated with the myogenic response in rat cerebral arteries.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Non-invasive micro-test technology and applications.Biophysics reports · 2025Article
- Vascular mechanotransduction.Physiological reviews · 2023Review
- Chloride Ions, Vascular Function and Hypertension.Biomedicines · 2022Review
- Calcium-Activated Chloride Channels in Myometrial and Vascular Smooth Muscle.Frontiers in physiology · 2021Review
- Measurement of extracellular ion fluxes using the ion-selective self-referencing microelectrode technique.Journal of visualized experiments : JoVE · 2015Article
- Regulation of vascular tone and arterial blood pressure: role of chloride transport in vascular smooth muscle.Pflugers Archiv : European journal of physiology · 2015Review
- Differential effect of calcium-activated potassium and chloride channels on rat basilar artery vasomotion.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Article
- TMEM16A/ANO1 channels contribute to the myogenic response in cerebral arteries.Circulation research · 2012Article
- Ion-selective self-referencing probes for measuring specific ion flux.Communicative & integrative biology · 2011Article
- The ClC-3 chloride channels in cardiovascular disease.Acta pharmacologica Sinica · 2011Review
- Differential recruitment of mechanisms for myogenic responses according to luminal pressure and arterial types.Pflugers Archiv : European journal of physiology · 2010Article
- Characterization of human SLC4A10 as an electroneutral Na/HCO3 cotransporter (NBCn2) with Cl- self-exchange activity.The Journal of biological chemistry · 2008Article
- Monitoring Cl- movement in single cells exposed to hypotonic solution.The Journal of membrane biology · 2005Article
- Rhythmical contractions in pulmonary arteries of monocrotaline-induced pulmonary hypertensive rats.Pflugers Archiv : European journal of physiology · 2003Article
- Differential activation of ion channels by inositol 1,4,5-trisphosphate (IP3)- and ryanodine-sensitive calcium stores in rat basilar artery vasomotion.The Journal of physiology · 2002Article
- Modulation of volume-sensitive chloride current by noradrenaline in rabbit portal vein myocytes.The Journal of physiology · 2002Article
- Measurement of chloride flux associated with the myogenic response in rat cerebral arteries.The Journal of physiology · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Self-referencing ion-selective (SERIS) electrodes were used to measure the temperature and pressure dependence of Cl(-) efflux, during myogenic contraction of pressurized rat cerebral resistance arteries. 2. At room temperature (18-21 degrees C), a small, pressure-independent Cl(-) efflux was measured. On warming to 37 degrees C, arteries developed pressure-dependent myogenic tone, and this was associated with a pressure-dependent increase in Cl(-) efflux (n = 5). 3. Both myogenic tone and the pressure- and temperature-dependent Cl(-) efflux were abolished on application of 10 microM tamoxifen, a Cl(-) channel blocker (IC(50) 3.75 +/- 0.2 microM). Tamoxifen (10 microM) also prevented contraction to 60 mM K(+), suggesting non-specific effects of tamoxifen (n = 5). 4. Myogenic tone was abolished by 2 microM nimodipine, but Cl(-) efflux was unaffected. In the presence of nimodipine, 10 microM tamoxifen still abolished pressure- and temperature-dependent Cl(-) efflux (n = 3). 5. In summary, a Cl(-) efflux can be measured from rat cerebral arteries, with a temperature dependence that is closely correlated with myogenic contraction. We conclude that Cl(-) efflux through Cl(-) channels contributes to the depolarization associated with myogenic contraction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.