ArticleThe Journal of physiology2001
Modulation of a presynaptic hyperpolarization-activated cationic current (I(h)) at an excitatory synaptic terminal in the rat auditory brainstem.
Article in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 140 citations in OpenAlex.
- Structural determinants of voltage sensitivity in hyperpolarization-activated ion channels and their persistence in the evolutionary scale.Pflugers Archiv : European journal of physiology · 2026Article
- A comprehensive review of HCN channel expression and IJournal of neurophysiology · 2025Review
- Selective Vulnerability of GABAergic Inhibitory Interneurons to Bilirubin Neurotoxicity in the Neonatal Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Targeting Affective Mood Disorders With Ketamine to Prevent Chronic Postsurgical Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- HCN channel-mediated neuromodulation can control action potential velocity and fidelity in central axons.eLife · 2019Article
- All four subunits of HCN2 channels contribute to the activation gating in an additive but intricate manner.The Journal of general physiology · 2018Article
- Activation gating in HCN2 channels.PLoS computational biology · 2018Article
- Developmental Changes in HCN Channel Modulation of Neocortical Layer 1 Interneurons.Frontiers in cellular neuroscience · 2018Article
- Accelerated Development of the First-Order Central Auditory Neurons With Spontaneous Activity.Frontiers in molecular neuroscience · 2018Article
- SK Channels Regulate Resting Properties and Signaling Reliability of a Developing Fast-Spiking Neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Cellular Computations Underlying Detection of Gaps in Sounds and Lateralizing Sound Sources.Trends in neurosciences · 2017Review
- Resistance to action potential depression of a rat axon terminal in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Degeneracy in the regulation of short-term plasticity and synaptic filtering by presynaptic mechanisms.The Journal of physiology · 2017Article
- Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.Hearing research · 2017Article
- ZD7288, a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.Neural regeneration research · 2016Article
- Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone.Frontiers in synaptic neuroscience · 2016Review
- Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides.Biophysical journal · 2015Article
- Nitric oxide selectively suppresses IH currents mediated by HCN1-containing channels.The Journal of physiology · 2015Article
- Article
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5 authors at 1 institution in 1 country.
Funding
Abstract
1. A hyperpolarization-activated non-specific cation current, I(h), was examined in bushy cell bodies and their giant presynaptic terminals (calyx of Held). Whole-cell patch clamp recordings were made using an in vitro brain slice preparation of the cochlear nucleus and the superior olivary complex. The aim was to characterise I(h) in identified cell bodies and synaptic terminals, to examine modulation by presynaptic cAMP and to test for modulatory effects of I(h) activation on synaptic transmission. 2. Presynaptic I(h) was activated by hyperpolarizing voltage-steps, with half-activation (V(1/2)) at -94 mV. Activation time constants were voltage dependent, showing an e-fold acceleration for hyperpolarizations of -32 mV (time constant of 78 ms at -130 mV). The reversal potential of I(h) was -29 mV. It was blocked by external perfusion of 1 mM CsCl but was unaffected by BaCl(2). 3. Application of internal cAMP shifted the activation curve to more positive potentials, giving a V(1/2) of -74 mV; hence around half of the current was activated at resting membrane potentials. This shift in half-activation was mimicked by external perfusion of a membrane-permeant analogue, 8-bromo-cAMP. 4. The bushy cell body I(h) showed similar properties to those of the synaptic terminal; V(1/2) was -94 mV and the reversal potential was -33 mV. Somatic I(h) was blocked by CsCl (1 mM) and was partially sensitive to BaCl(2). Somatic I(h) current density increased with postnatal age from 5 to 16 days old, suggesting that I(h) is functionally relevant during maturation of the auditory pathway. 5. The function of I(h) in regulating presynaptic excitability is subtle. I(h) had little influence on EPSC amplitude at the calyx of Held, but may be associated with propagation of the action potential at branch points. Presynaptic I(h) shares properties with both HCN1 and HCN2 recombinant channel subunits, in that it gates relatively rapidly and is modulated by internal cAMP.
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