ReviewThe Journal of physiology2001
Compartmental neurodegeneration and synaptic plasticity in the Wld(s) mutant mouse.
Review in The Journal of physiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed.
- Neuronal expression of S100B triggered by oligomeric AFrontiers in molecular neuroscience · 2025Article
- Identification and characterization ofClinical case reports · 2024Article
- Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3.Cell & bioscience · 2023Article
- A method to identify, dissect and stain equine neuromuscular junctions for morphological analysis.Journal of anatomy · 2022Article
- Of axons that struggle to make ends meet: Linking axonal bioenergetic failure to programmed axon degeneration.Biochimica et biophysica acta. Bioenergetics · 2022Review
- In vivo imaging of injured cortical axons reveals a rapid onset form of Wallerian degeneration.BMC biology · 2020Article
- Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis.Journal of neuroinflammation · 2017Article
- Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease.The American journal of pathology · 2016Article
- Some reminiscences on studies of age-dependent and activity-dependent degeneration of sensory and motor endings in mammalian skeletal muscle.Journal of anatomy · 2015Review
- Activity-dependent degeneration of axotomized neuromuscular synapses in Wld S mice.Neuroscience · 2015Article
- A unified cell biological perspective on axon-myelin injury.The Journal of cell biology · 2014Review
- Morphological analysis of neuromuscular junction development and degeneration in rodent lumbrical muscles.Journal of neuroscience methods · 2014Article
- The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction.Cell reports · 2013Article
- Article
- UBE4B: a promising regulatory molecule in neuronal death and survival.International journal of molecular sciences · 2012Review
- Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration.Nature genetics · 2012Article
- Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.BMC medicine · 2012Article
- A pivotal role of GSK-3 in synaptic plasticity.Frontiers in molecular neuroscience · 2012Article
- ApoE isoform-specific regulation of regeneration in the peripheral nervous system.Human molecular genetics · 2011Article
- Theiler's virus infection: Pathophysiology of demyelination and neurodegeneration.Pathophysiology : the official journal of the International Society for Pathophysiology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This review focuses on recent developments in our understanding of neurodegeneration at the mammalian neuromuscular junction. We provide evidence to support a hypothesis of compartmental neurodegeneration, whereby synaptic degeneration occurs by a separate, distinct mechanism from cell body and axonal degeneration. Studies of the spontaneous mutant Wld(s) mouse, in which Wallerian degeneration is characteristically slow, provide key evidence in support of this hypothesis. Some features of synaptic degeneration in the absence of Wallerian degeneration resemble synapse elimination in neonatal muscle. This and other forms of synaptic plasticity may be accessible to further investigations, exploiting advantages afforded by the Wld(s) mutant, or transgenic mice that express the Wld(s) gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.