ArticleThe EMBO journal2001
Regulation of BOB.1/OBF.1 stability by SIAH.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 74 citations in OpenAlex.
- Parallel Selection for Longevity in Mammals and Birds.bioRxiv : the preprint server for biology · 2025Article
- The Role of the Transcriptional Coactivator BOB.1/OBF.1 in Adaptive Immunity.Advances in experimental medicine and biology · 2024Review
- PHF19 promotes the proliferation, migration, and chemosensitivity of glioblastoma to doxorubicin through modulation of the SIAH1/β-catenin axis.Cell death & disease · 2018Article
- A C-terminal acidic domain regulates degradation of the transcriptional coactivator Bob1.Molecular and cellular biology · 2013Article
- SIAH proteins: critical roles in leukemogenesis.Leukemia · 2013Review
- Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1.Molecular and cellular biochemistry · 2011Article
- USP13 enzyme regulates Siah2 ligase stability and activity via noncatalytic ubiquitin-binding domains.The Journal of biological chemistry · 2011Article
- Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes.Journal of experimental & clinical cancer research : CR · 2010Article
- E2F1 represses beta-catenin/TCF activity by direct up-regulation of Siah1.Journal of cellular and molecular medicine · 2009Article
- The ubiquitin ligase Siah2 and the hypoxia response.Molecular cancer research : MCR · 2009Review
- An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.Nature cell biology · 2009Article
- Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia.The EMBO journal · 2008Article
- SIAH-1 interacts with the Kaposi's sarcoma-associated herpesvirus-encoded ORF45 protein and promotes its ubiquitylation and proteasomal degradation.Journal of virology · 2008Article
- Two modes of degradation of the tramtrack transcription factors by Siah homologues.The Journal of biological chemistry · 2008Article
- Enforced expression of the transcriptional coactivator OBF1 impairs B cell differentiation at the earliest stage of development.PloS one · 2008Article
- Siah-1S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of beta-catenin.Oncogene · 2007Article
- BOB.1/OBF.1 controls the balance of TH1 and TH2 immune responses.The EMBO journal · 2007Article
- Regulation of the ring finger E3 ligase Siah2 by p38 MAPK.The Journal of biological chemistry · 2006Article
- The Ets factor Spi-B is a direct critical target of the coactivator OBF-1.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?Oncogene · 2004Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The BOB.1/OBF.1 coactivator is critically involved in mediating octamer-dependent transcriptional activity in B lymphocytes. Mice lacking this coactivator show various defects in B-cell development, most notably they completely lack germinal centers. Consistent with this phenotype, BOB.1/OBF.1 levels are massively upregulated in germinal center B cells as compared with resting B cells. We have addressed the mechanism of upregulation and found that only a minor part of this regulation can be attributed to increased levels of BOB.1/OBF.1-specific mRNA. Apparently, BOB.1/OBF.1 is also regulated at the protein level. In support of this suggestion we have been able to identify two related BOB.1/OBF.1 interacting proteins, SIAH1 and SIAH2, in a yeast two-hybrid screen. SIAH1 and SIAH2 are known regulators of protein stability. Cotransfection experiments revealed that coexpression of SIAH results in a destabilization of BOB.1/OBF.1 protein without affecting mRNA levels. Further more, proteasome inhibitors block the degradation of BOB.1/OBF.1 protein. Finally, B-cell receptor cross-linking also resulted in the degradation of BOB.1/OBF.1 and consequently reduced transcriptional activation of BOB.1/OBF.1-dependent reporters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.