ArticleThe EMBO journal2001
Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif.
Article in The EMBO journal, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- MoScd2 is involved in appressorium formation and pathogenicity via the Pmk1 MAPK pathway in Magnaporthe oryzae.Crop health · 2023Article
- Deep Evolutionary History of the Phox and Bem1 (PB1) Domain Across Eukaryotes.Scientific reports · 2020Article
- Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ-p53-p21 signaling pathway.Cell death & disease · 2017Article
- Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity.Scientific reports · 2017Article
- A Split-Ubiquitin Based Strategy Selecting for Protein Complex-Interfering Mutations.G3 (Bethesda, Md.) · 2016Article
- Transcriptome-wide functional characterization reveals novel relationships among differentially expressed transcripts in developing soybean embryos.BMC genomics · 2015Article
- Cdc42 GTPase dynamics control directional growth responses.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Significant role of PB1 and UBA domains in multimerization of Joka2, a selective autophagy cargo receptor from tobacco.Frontiers in plant science · 2014Article
- The atypical PKCs in inflammation: NF-κB and beyond.Immunological reviews · 2012Review
- Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain.EMBO reports · 2011Article
- Solution structure of a novel Cdc42 binding module of Bem1 and its interaction with Ste20 and Cdc42.The Journal of biological chemistry · 2010Article
- The structural and functional determinants of the Axin and Dishevelled DIX domains.BMC structural biology · 2009Article
- Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1).Molecular cancer therapeutics · 2009Article
- The Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localization.The EMBO journal · 2007Article
- Central roles of small GTPases in the development of cell polarity in yeast and beyond.Microbiology and molecular biology reviews : MMBR · 2007Review
- Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding.The EMBO journal · 2007Article
- Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes.PLoS computational biology · 2006Article
- PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation.Molecular and cellular biology · 2006Article
- A modified strategy for sequence specific assignment of protein NMR spectra based on amino acid type selective experiments.Journal of biomolecular NMR · 2005Article
- Separate membrane targeting and anchoring domains function in the localization of the S. cerevisiae Cdc24p guanine nucleotide exchange factor.Current genetics · 2004Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PB1 domains are novel protein modules capable of binding to target proteins that contain PC motifs. We report here the NMR structure and ligand-binding site of the PB1 domain of the cell polarity establishment protein, Bem1p. In addition, we identify the topology of the PC motif-containing region of Cdc24p by NMR, another cell polarity establishment protein that interacts with Bem1p. The PC motif-containing region is a structural domain offering a scaffold to the PC motif. The chemical shift perturbation experiment and the mutagenesis study show that the PC motif is a major structural element that binds to the PB1 domain. A structural database search reveals close similarity between the Bem1p PB1 domain and the c-Raf1 Ras-binding domain. However, these domains are functionally distinct from each other.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.