ArticleProceedings of the National Academy of Sciences of the United States of America2001
Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 85 citations in OpenAlex.
- Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms.Frontiers in endocrinology · 2023Review
- Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions.Pharmacological reports : PR · 2022Review
- Thyroid Hormone Deiodinases: Dynamic Switches in Developmental Transitions.Endocrinology · 2021Review
- The Clinical Spectrum of Resistance to Thyroid Hormone Alpha in Children and AdultsJournal of clinical research in pediatric endocrinology · 2021Review
- Temporal Pole Responds to Subtle Changes in Local Thyroid Hormone Signaling.Journal of the Endocrine Society · 2020Article
- RNA SEQ Analysis Indicates that the AE3 ClScientific reports · 2017Article
- Nuclear receptors and the Warburg effect in cancer.International journal of cancer · 2015Review
- Resistance to thyroid hormone due to defective thyroid receptor alpha.Best practice & research. Clinical endocrinology & metabolism · 2015Review
- Clinical Consequences of Mutations in Thyroid Hormone Receptor-α1.European thyroid journal · 2014Review
- Thyroid hormone role on cerebellar development and maintenance: a perspective based on transgenic mouse models.Frontiers in endocrinology · 2014Review
- Making sense with thyroid hormone--the role of T(3) in auditory development.Nature reviews. Endocrinology · 2013Review
- Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Cerebellar abnormalities in mice lacking type 3 deiodinase and partial reversal of phenotype by deletion of thyroid hormone receptor α1.Endocrinology · 2013Article
- Genome-wide search reveals the existence of a limited number of thyroid hormone receptor alpha target genes in cerebellar neurons.PloS one · 2012Article
- Differential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Thyroid hormone action in metabolic regulation.Protein & cell · 2011Review
- Physiological consequences of the TRalpha1 aporeceptor state.Heart failure reviews · 2010Review
- Animal models to study thyroid hormone action in cerebellum.Cerebellum (London, England) · 2009Review
- Multigenic control of thyroid hormone functions in the nervous system.Molecular and cellular endocrinology · 2008Review
- Thyroid hormone and cerebellar development.Cerebellum (London, England) · 2008Review
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain glucose utilization is markedly depressed in adult rats made cretinous after birth. To ascertain which subtype of thyroid hormone (TH) receptors, TRalpha1 or TRbeta, is involved in the regulation of glucose utilization during brain development, we used the 2-[(14)C]deoxyglucose method in mice with a mutation in either their TRalpha or TRbeta gene. A C insertion produced a frameshift mutation in their carboxyl terminus. These mutants lacked TH binding and transactivation activities and exhibited potent dominant negative activity. Glucose utilization in the homozygous TRbetaPV mutant mice and their wild-type siblings was almost identical in 19 brain regions, whereas it was markedly reduced in all brain regions of the heterozygous TRalpha1PV mice. These suggest that the alpha1 receptor mediates the TH effects in brain. Inasmuch as local cerebral glucose utilization is closely related to local synaptic activity, we also examined which thyroid hormone receptor is involved in the expression of synaptotagmin-related gene 1 (Srg1), a TH-positively regulated gene involved in the formation and function of synapses [Thompson, C. C. (1996) J. Neurosci. 16, 7832-7840]. Northern analysis showed that Srg1 expression was markedly reduced in the cerebellum of TRalpha(PV/+) mice but not TRbeta(PV/PV) mice. These results show that the same receptor, TRalpha1, is involved in the regulation by TH of both glucose utilization and Srg1 expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.