ReviewCurrent opinion in chemical biology2001
Random-peptide libraries and antigen-fragment libraries for epitope mapping and the development of vaccines and diagnostics.
Review in Current opinion in chemical biology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
69 citing papers in PubMed, 180 citations in OpenAlex.
- Reconstructing pathogen-specific antibody binding epitopes and age-dependent immune signatures from proteomic-scale peptide libraries.Science advances · 2026Article
- Review
- Identification of Antibody-Mediated Hydrolysis Sites of Oligopeptides Corresponding to the SARS-CoV-2 S-Protein by MALDI-TOF Mass Spectrometry.International journal of molecular sciences · 2023Article
- Article
- Epitopes and Mimotopes Identification Using Phage Display for Vaccine Development against Infectious Pathogens.Vaccines · 2023Review
- Hydrogen Deuterium Exchange and other Mass Spectrometry-based Approaches for Epitope Mapping.Frontiers in analytical science · 2023Article
- Article
- PhIP-Seq Reveals Autoantibodies for Ubiquitously Expressed Antigens in Viral Myocarditis.Biology · 2022Article
- Emerging Computational Approaches for Antimicrobial Peptide Discovery.Antibiotics (Basel, Switzerland) · 2022Review
- An overview of methods for the structural and functional mapping of epitopes recognized by anti-SARS-CoV-2 antibodies.RSC chemical biology · 2021Review
- A next generation sequencing (NGS) analysis to reveal genomic and proteomic mutation landscapes of SARS-CoV-2 in South Asia.Current research in microbial sciences · 2021Article
- Prediction of B cell and T-helper cell epitopes candidates of bovine leukaemia virus (BLV) by in silico approach.Veterinary medicine and science · 2020Article
- An immunoinformatics study on the spike protein of SARS-CoV-2 revealing potential epitopes as vaccine candidates.Heliyon · 2020Article
- Structural Features of a Conformation-dependent Antigen Epitope on ORFV-B2L Recognized by the 2E4 mAb.Scientific reports · 2019Article
- The development of inovirus-associated vector vaccines using phage-display technologies.Expert review of vaccines · 2019Review
- Virus-Derived Peptides for Clinical Applications.Chemical reviews · 2017Review
- SEPIa, a knowledge-driven algorithm for predicting conformational B-cell epitopes from the amino acid sequence.BMC bioinformatics · 2017Article
- Article
- Phage display as a promising approach for vaccine development.Journal of biomedical science · 2016Review
- Characterization of fine specificity of the immune response to a Plasmodium falciparum rhoptry neck protein, PfAARP.Malaria journal · 2016Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Random peptide libraries and antigen-fragment libraries (also known as gene-fragment libraries) have been used to identify epitopes on protein antigens. These technologies promise to make significant contributions to diagnostic and vaccine development. Researchers in a number of labs have shown that phage selected from libraries with protective antibodies, raised against whole antigen, can be used as immunogens to stimulate antibody responses that bind native antigen and provide protection in vivo. Others have used the sera of patients with idiopathic diseases to screen libraries, and by this approach have identified candidate antigens involved in immune disease. These may prove useful for diagnosis and, possibly, in determining disease etiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.