ArticleGenes and immunity2001
A genome screen for multiple sclerosis in Italian families.
Article in Genes and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Meta-analysis of genome-wide linkage studies across autoimmune diseases.European journal of human genetics : EJHG · 2009Pooled it
- Mapping candidate non-MHC susceptibility regions to multiple sclerosis.Genes and immunity · 2006Pooled it
- Article
- Association of interleukin 7 receptor gene polymorphism rs6897932 with multiple sclerosis patients in Khuzestan.Iranian journal of neurology · 2014Article
- The genetic aspects of multiple sclerosis.Annals of Indian Academy of Neurology · 2009Article
- Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.Genes and immunity · 2009Article
- A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility.Journal of neuroimmunology · 2009Article
- The complex genetics of multiple sclerosis: pitfalls and prospects.Brain : a journal of neurology · 2008Review
- The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome.Journal of neurology · 2007Article
- A genome-wide scan in forty large pedigrees with multiple sclerosis.Journal of human genetics · 2007Article
- Follow-up investigation of 12 proposed linkage regions in multiple sclerosis.Genes and immunity · 2006Article
- Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44.Genes and immunity · 2006Article
- A high-density screen for linkage in multiple sclerosis.American journal of human genetics · 2005Article
- Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis.Genetics · 2005Article
- A second-generation genomic screen for multiple sclerosis.American journal of human genetics · 2004Article
- Investigation of seven proposed regions of linkage in multiple sclerosis: an American and French collaborative study.Neurogenetics · 2004Article
- A genome screen for linkage in Australian sibling-pairs with multiple sclerosis.Genes and immunity · 2002Article
- A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis.Genes and immunity · 2002Article
- Genetic analysis of multiple sclerosis.Current neurology and neuroscience reports · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have screened the whole genome for linkage in 40 Italian multiplex families with multiple sclerosis using 322 markers. The GENEHUNTER-PLUS program was used to analyse these data and revealed eight regions of potential linkage where the lod score exceeds the nominal 5% significance level (0.7). No region of linkage with genome-wide significance was identified and none of the markers showed evidence of statistically significant transmission disequilibrium. Overall these results have refined the linkage data relating to this disease in Italians modestly supporting some previously identified areas of interest and helping to exclude others.
Indexed as
Identifiers
11477475What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.