ArticleGenes and immunity2001
Association and linkage of leprosy phenotypes with HLA class II and tumour necrosis factor genes.
Article in Genes and immunity, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed.
- Reanalysis and integration of public microarray datasets reveals novel host genes modulated in leprosy.Molecular genetics and genomics : MGG · 2020Article
- Advances in the Immunology and Genetics of Leprosy.Frontiers in immunology · 2020Review
- Review
- Transcriptional changes that characterize the immune reactions of leprosy.The Journal of infectious diseases · 2015Article
- Gene Association with Leprosy: A Review of Published Data.Frontiers in immunology · 2015Review
- Leprosy in the 21st century.Clinical microbiology reviews · 2015Review
- The +3187A/G HLA-G polymorphic site is associated with polar forms and reactive reaction in leprosy.Molecular genetics & genomic medicine · 2013Article
- Role of HLA, KIR, MICA, and cytokines genes in leprosy.BioMed research international · 2013Review
- Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase.Journal of tropical medicine · 2012Article
- Chronic or late lyme neuroborreliosis: analysis of evidence compared to chronic or late neurosyphilis.The open neurology journal · 2012Article
- Tumour necrosis factor gene polymorphism and disease prevalence.Scandinavian journal of immunology · 2011Review
- Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.Journal of neuroinflammation · 2011Review
- Human leukocyte antigen class I region single-nucleotide polymorphisms are associated with leprosy susceptibility in Vietnam and India.The Journal of infectious diseases · 2011Article
- Leprosy as a genetic disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Human polymorphisms as clinical predictors in leprosy.Journal of tropical medicine · 2011Article
- Leprosy and the human genome.Microbiology and molecular biology reviews : MMBR · 2010Review
- IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians.Human genetics · 2010Article
- Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes.Human immunology · 2010Article
- HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance.BMC infectious diseases · 2009Article
- Leprosy as a genetic model for susceptibility to common infectious diseases.Human genetics · 2008Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous analyses indicate major gene control of susceptibility to leprosy per se and the HLA class II region has been implicated in determining susceptibility and control of clinical phenotype. Segregation analysis using data from 76 Brazilian leprosy multi-case pedigrees (1166 individuals) supported a two locus model as the best fit: a recessive major gene and a recessive modifier gene(s) (single locus vs two locus model, P = 0.0007). Combined segregation and linkage analysis to the major locus, showed strong linkage to HLA class II (HLA-DQB1 P = 0.000002, HLA-DQA1 P = 0.000002, HLA-DRB1 P = 0.0000003) and tumour necrosis factor genes (TNF P = 0.00002, LTA P = 0.003). Extended transmission disequilibrium testing, using multiple affected family members, demonstrated that the common allele TNF*1 of the -308 promoter region polymorphism showed linkage and/or association with disease per se, at a high level of significance (P < 0.0001). Two locus transmission disequilibrium testing suggested susceptibility (TNF*1/LTA*2) and protective (TNF*2/LTA*2) haplotypes in the class iii region. Taken together the segregation and HLA analyses suggest the possibility of more than one susceptibility locus in the MHC.
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Registered trials
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