ReviewMolecular pathology : MP2001
What we could do now: molecular pathology of colorectal cancer.
Review in Molecular pathology : MP, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 73 citations in OpenAlex.
- The Role of Nuclear Receptor Subfamily 1 Group H Member 4 (NR1H4) in Colon Cancer Cell Survival through the Regulation of c-Myc Stability.Molecules and cells · 2020Article
- Brain Metastasis as Initial Presentation of Rectal Adenocarcinoma: an Unusual Case in a Very Young Patient.Journal of gastrointestinal cancer · 2018Article
- Dehydropeptidase 1 promotes metastasis through regulation of E-cadherin expression in colon cancer.Oncotarget · 2016Article
- A novel AMPK activator reduces glucose uptake and inhibits tumor progression in a mouse xenograft model of colorectal cancer.Investigational new drugs · 2014Article
- Protein pathway activation mapping of colorectal metastatic progression reveals metastasis-specific network alterations.Clinical & experimental metastasis · 2013Article
- DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness.Journal of gastroenterology · 2011Article
- A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy.The oncologist · 2010Review
- Association of colorectal adenoma with other malignancies in Swedish families.British journal of cancer · 2008Article
- Novel hMSH2, hMSH6 and hMLH1 gene mutations and microsatellite instability in sporadic colorectal cancer.Journal of cancer research and clinical oncology · 2007Article
- Over-expressed estrogen receptor-alpha up-regulates hTNF-alpha gene expression and down-regulates beta-catenin signaling activity to induce the apoptosis and inhibit proliferation of LoVo colon cancer cells.Molecular and cellular biochemistry · 2006Article
- Genetic alteration and gene expression modulation during cancer progression.Molecular cancer · 2004Review
- DNA variants in the ATM gene are not associated with sporadic rectal cancer in a Norwegian population-based study.International journal of colorectal disease · 2004Article
- [Clinical, pathological and molecular prognostic factors in colorectal carcinomas].Der Pathologe · 2003Review
- Molecular pathology of solid tumours: translating research into clinical practice. Introduction and overview.Molecular pathology : MP · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contribution of molecular genetics to colorectal cancer has been largely restricted to relatively rare inherited tumours and to the detection of germ line mutations predisposing to these cancers. However, much is now known about the somatic events leading to colorectal cancer in general. Several studies have examined the relation between genetic features and prognosis. The purpose of this article is to review these studies and summarise the current state of this subject. Although many of the published studies are small and inconclusive, it is clear that several different pathways exist for the development of this cancer, and some molecular characteristics seem to correlate with clinicopathological features. At present, studies are confined to evaluating a small number of molecular markers; however, with the advent of methods for the rapid genetic profiling of large numbers of colorectal cancers, it will be possible to evaluate fully the clinical usefulness of a range of colorectal cancer genotypes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.