ArticleJournal of clinical pathology2001
Bacterial translocation and immunohistochemical measurement of gut immune function.
Article in Journal of clinical pathology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 41 citations in OpenAlex.
- Small Intestinal Bacterial Overgrowth and Childhood Malnutrition: A Comprehensive Review of Available Evidence.Nutrients · 2024Review
- Differential Effect of Light and Dark Period Sleep Fragmentation on Composition of Gut Microbiome and Inflammation in Mice.Life (Basel, Switzerland) · 2021Article
- Inflammation and Overlap of Irritable Bowel Syndrome and Functional Dyspepsia.Journal of neurogastroenterology and motility · 2021Review
- Procalcitonin, and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites.World journal of gastroenterology · 2014Article
- Disease dependent qualitative and quantitative differences in the inflammatory response to ascites occurring in cirrhotics.World journal of hepatology · 2014Article
- Probiotics can alleviate cardiopulmonary bypass-induced intestinal mucosa damage in rats.Digestive diseases and sciences · 2013Article
- Cirrhotic ascites review: Pathophysiology, diagnosis and management.World journal of hepatology · 2013Article
- Association Between Appendectomy and Fibrosis Progression in Nonalcoholic Fatty Liver Disease.Gastroenterology research · 2013Article
- Effects of the oral administration of viable and heat-killed Streptococcus bovis HC5 cells to pre-sensitized BALB/c mice.PloS one · 2012Article
- The Relationship between Small-Intestinal Bacterial Overgrowth and Intestinal Permeability in Patients with Irritable Bowel Syndrome.Gut and liver · 2009Article
- Small intestinal bacterial overgrowth in patients with interstitial cystitis and gastrointestinal symptoms.Digestive diseases and sciences · 2008Article
- The effects of long-term total parenteral nutrition on gut mucosal immunity in children with short bowel syndrome: a systematic review.BMC nursing · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe local immune response in the small bowel mucosa might play a role in bacterial translocation (BT). The aim of this study was to quantify immune cells and secretory antibodies in the small bowel mucosa, and relate this to BT as assessed by culture of a mesenteric lymph node.
methodsImmunohistochemical techniques were used to measure the frequency of plasma cells and IgA and IgM positive cells in the lamina propria and semiquantitatively to assess mucosal surface IgA and IgM values in small bowel specimens obtained from 11 patients in whom positive evidence of BT had been identified in a mesenteric lymph node harvested at the time of laparotomy. These were compared with similar specimens obtained from 11 patients in whom a similar lymph node had yielded no growth.
resultsBT was associated with a significantly increased median frequency of plasma cells (p < 0.01) and IgA positive cells (p < 0.05) in the lamina propria. The frequency of IgM positive cells was also higher in these patients, although this difference was not significant. In addition, semiquantitatively scored IgA and IgM concentrations at the mucosal surface were both significantly higher in the patients in whom BT had been identified (p = 0.006 and 0.016, respectively).
conclusionHigher numbers of plasma cells and higher IgA and IgM values are present in the small bowel mucosa of patients in whom BT has been shown to occur, suggesting an increased local immune response.
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