ReviewBritish journal of sports medicine2001
Sepsis and mechanisms of inflammatory response: is exercise a good model?
Review in British journal of sports medicine, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 39 citations in OpenAlex.
- Exercise-derived peptide confers protection against septic cardiomyopathy by enhancing CCAAT/enhancer binding protein β-mediated autophagy.Cellular and molecular life sciences : CMLS · 2025Article
- Article
- Acute phase reactions inThe journal of venomous animals and toxins including tropical diseases · 2024Article
- Repetitive Bouts of Exhaustive Exercise Induces a Systemic Inflammatory Response and Multi-Organ Damage in Rats.Frontiers in physiology · 2020Article
- Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure.Journal of clinical medicine · 2019Article
- Cerebrospinal fluid and plasma β-endorphin levels in children with cerebral malaria.Brain and behavior · 2017Article
- Inadequate exercise as a risk factor for sepsis mortality.PloS one · 2013Article
- Do physiological and pathological stresses produce different changes in heart rate variability?Frontiers in physiology · 2013Article
- Pentraxin3 and high-sensitive C-reactive protein are independent inflammatory markers released during high-intensity exercise.European journal of applied physiology · 2010Article
- Trauma-induced systemic inflammatory response versus exercise-induced immunomodulatory effects.Sports medicine (Auckland, N.Z.) · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe immune changes induced by a bout of prolonged and vigorous exercise have been suggested to be a useful experimental model of sepsis and the inflammatory response. Available literature was reviewed to evaluate this hypothesis.
methodsLiterature describing the immune response to various patterns of exercise was compared with data on the immune changes observed during sepsis and inflammation.
resultsAlthough there are qualitative similarities between the immune responses to exercise and sepsis, the magnitude of the changes induced by most forms of exercise remains much smaller than in a typical inflammatory response. Indeed, the exercise induced changes in some key elements such as plasma cytokine concentrations are too small to be detected reliably by current technology.
conclusionsIf exercise is to provide a valid model of sepsis and the inflammatory response, it will be necessary to focus on subjects who are willing to exercise extremely hard, to use the pattern of exercise that has the greatest effect on the immune system, and to combine this stimulus with other psychological, environmental, or nutritional stressors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.