ArticleBMC microbiology2001
Low frequency of mutations in the core promoter and precore regions of hepatitis B virus in anti-HBe positive Brazilian carriers.
Article in BMC microbiology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Correlation Between Hepatitis B G1896A Precore Mutations and HBeAg in Chronic HBV Patients.Jundishapur journal of microbiology · 2015Article
- Hepatitis B virus lineages in mammalian hosts: potential for bidirectional cross-species transmission.World journal of gastroenterology · 2014Review
- Mutations in pre-core and basal-core promoter regions of hepatitis B virus in chronic HBV patients from Golestan, Iran.Iranian journal of basic medical sciences · 2014Article
- Etiology and Viral Genotype in Patients with End-Stage Liver Diseases admitted to a Hepatology Unit in Colombia.Hepatitis research and treatment · 2011Article
- Hepatitis B virus genotypes and precore and core mutants in UAE patients.Virology journal · 2010Article
- Virological pattern of hepatitis B infection in an HIV-positive man with fatal fulminant hepatitis B: a case report.Journal of medical case reports · 2009Article
- Hepatitis B virus genotypes circulating in Brazil: molecular characterization of genotype F isolates.BMC microbiology · 2007Article
- Evaluation of liver tissue by polymerase chain reaction for hepatitis B virus in patients with negative viremia.World journal of gastroenterology · 2005Article
- Strong association between genotype F and hepatitis B virus (HBV) e antigen-negative variants among HBV-infected argentinean blood donors.Journal of clinical microbiology · 2004Article
- Hepatitis B virus genotypes and precore and core mutants in Brazilian patients.Journal of clinical microbiology · 2004Article
- Hepatitis B virus in the State of Alagoas, Brazil: genotypes characterization and mutations of the precore and basal core promoter regions.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesArticle
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3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundMutations in the core promoter and precore regions of the hepatitis B virus (HBV) genome, notably the double substitution (AGG to TGA) at nt positions 1762-1764 in the core promoter, and the precore stop codon mutation G to A at nt 1896, can often explain the anti-HBe phenotype in chronic carriers. However, the A1896 mutation is restricted to HBV isolates that have T at nt 1858. The double substitution at positions 1762-1764 has been described to occur preferentially in patients infected with strains showing C instead of T at nt 1858.
resultsHBV DNAs from 29 anti-HBe Brazilian samples were characterized by nucleotide sequencing of PCR products from precore region. Among them, 18 isolates presented C at nt 1858 (mostly genotype A strains). The 11 remaining isolates (genotypes D and F) had T1858. The stop codon mutation at nt 1896 was found in seven isolates (24% of the total and 63% of the isolates that had T1858). The frequency of the double substitution at positions 1762-1764 was surprisingly low (20%) among C1858 isolates. An association between A1896 and TGA 1762-1764 mutations was observed among genotype D isolates: these showed either none of the two mutations or both. Furthermore, strains mutated at positions 1896 and/or 1762-1764 also presented an elevated number of other, less common substitutions in the core promoter and precore regions.
conclusionsThe data reported here are not in accordance with some reports from other parts of the world. In half of the isolates, none of the mutations previously described could explain the anti-HBe phenotype.
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