ArticleClinical and experimental immunology2001
Inter-individual differences in cytokine release in patients undergoing cardiac surgery with cardiopulmonary bypass.
Article in Clinical and experimental immunology, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 63 citations in OpenAlex.
- REmoval of cytokines during CArdiac surgery (RECCAS): a randomised controlled trial.Critical care (London, England) · 2024Trial
- Longer RBC storage duration is associated with increased postoperative infections in pediatric cardiac surgery.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2015Trial
- Safety and effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients: a randomized double-blind, dose-dependent, phase IV clinical trial.Journal of cardiothoracic surgery · 2011Trial
- Review
- Robotics versus open surgery: the impact on cytokine release and patient outcomes.Journal of robotic surgery · 2025Review
- Monocyte Metabolism and Function in Patients Undergoing Cardiac Surgery.Frontiers in cardiovascular medicine · 2022Article
- The Protection of Crocin Against Ulcerative Colitis and Colorectal Cancer via Suppression of NF-κB-Mediated Inflammation.Frontiers in pharmacology · 2021Article
- Effects of Orally Administered Resveratrol on TNF, IL-1β, Leukocyte Phagocytic Activity and Oxidative Burst Function in Horses: A Prospective, Randomized, Double-Blinded, Placebo-Controlled Study.International journal of molecular sciences · 2020Article
- Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins.Journal of Alzheimer's disease : JAD · 2018Article
- Influence of the postoperative inflammatory response on cognitive decline in elderly patients undergoing on-pump cardiac surgery: a controlled, prospective observational study.BMC anesthesiology · 2017Observational
- Role of Postoperative C-Reactive Protein Levels in Predicting Prognosis After Surgical Treatment of Esophageal Cancer.World journal of surgery · 2017Article
- Tumor necrosis factor-α -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients.World journal of gastroenterology · 2016Article
- Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2016Observational
- Dynamic changes in HMGB1 levels correlate with inflammatory responses during cardiopulmonary bypass.Experimental and therapeutic medicine · 2013Article
- Elevated S100A12 and sRAGE are associated with increased length of hospitalization after non-urgent coronary artery bypass grafting surgery.American journal of cardiovascular disease · 2013Article
- Association of the 98T ELAM-1 polymorphism with increased bleeding after cardiac surgery.Journal of cardiothoracic and vascular anesthesia · 2010Article
- Bench-to-bedside review: Association of genetic variation with sepsis.Critical care (London, England) · 2009Review
- Pharmacogenomics and end-organ susceptibility to injury in the perioperative period.Best practice & research. Clinical anaesthesiology · 2008Review
- Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiac surgery with cardiopulmonary bypass (CPB) leads to a systemic inflammatory response with secretion of cytokines (e.g. IL-6, TNF-alpha, IL-1 beta and sIL-2R). The objective of the following study was to investigate in vitro and in vivo cytokine responses and white blood cell counts (WBC) of patients with high versus low cytokine secretion after a coronary artery bypass grafting (CABG) procedure. Twenty male patients undergoing elective CABG surgery with CPB under general anaesthesia were enrolled in the study. On the day of surgery (postoperatively), serum levels of TNF-alpha and IL-1 beta were significantly higher in patients of the high IL-6 level group compared to the respective values in the patient group with low IL-6 levels. The inter-individual differences in IL-6 release in patients undergoing CABG surgery with CPB were accompanied by differences in the release of other cytokines, such as TNF-alpha, IL-1 beta and sIL-2R. To understand whether genetic background plays a role in influencing cytokine plasma levels under surgical stress, we examined the distribution of polymorphic elements within the promoter regions of the TNF-alpha and IL-6 genes, and determined their genotype regarding the BAT2 gene and TNF-beta intron polymorphisms. Our preliminary data suggests that regulatory polymorphisms in or near the TNF locus, more precisely the allele set 140/150 of the BAT2 microsatellite marker combined with the G allele at -308 of the TNF-alpha gene, could be one of the genetic constructions providing for a less sensitive response to various stimuli. Our results suggest: (1) close relationships between cytokine release in the postoperative period, and (2) inter-individually varying patterns of cytokine release in patients undergoing CABG surgery with CPB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.